Results 211 to 220 of about 41,836 (256)

The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor

Regulatory Peptides, 2008
In this study, we identified the multifunctional protein GC1q-R as a novel vasopressin V(2) receptor (V(2)R) interacting protein. For this purpose, we have developed a proteomic approach combining pull-down assays using a cyclic peptide mimicking the third intracellular loop of V(2)R as a bait and mass spectrometry analyses of proteins isolated from ...
Granier, Sebastien, Jean-Alphonse, Frederic, Bacqueville, Daniel, Monteil, Arnaud, Pascal, Robert, Poncet, Joel, Guillon, Gilles, Boudier, Laure, Arcemisbehere, Laure, Mouillac, Bernard, Bellot, Gaetan, Demene, Helene, Mendre, Christiane   +12 more
openaire   +3 more sources

Arginine vasopressin stimulates H⁺-ATPase in MDCK cells via V₁(cell Ca²⁺) and V₂(cAMP) receptors

American Journal of Physiology-Renal Physiology, 2004
The effect of arginine vasopressin (AVP) and/or atrial natriuretic peptide (ANP) on the regulation of intracellular pH (pHi) via H+-ATPase and of cytosolic calcium ([Ca2+]i) was investigated in Madin-Darby canine kidney (MDCK) cells by the fluorescent probes BCECF-AM and fluo-4-AM, respectively.
Maria Oliveira‐Souza, Raif Musa‐Aziz, Gerhard Malnic, Margarida de Mello Aires   +3 more
openalex   +3 more sources

2,5‐Disubstituted 3,4‐Dihydro‐2H‐benzo[b][1,4]thiazepines as Potent and Selective V₂ Arginine Vasopressin Receptor Antagonists.

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Maud Urbanski, Robert H. Chen, Keith T. Demarest, Joseph W. Gunnet, Richard Look, Eric Ericson, William V. Murray, Philip J. Rybczynski, Xiaoyan Zhang   +8 more
openalex   +3 more sources

Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia

Journal of Cerebral Blood Flow & Metabolism, 2005
Brain edema formation is one of the most important mechanisms responsible for brain damage after ischemic stroke. Despite considerable efforts, no specific therapy is available yet. Arginine vasopressin (AVP) regulates cerebral water homeostasis and has been involved in brain edema formation.
Abedin, Vakili, Hiroharu, Kataoka, Nikolaus, Plesnila   +2 more
openaire   +2 more sources

Properties of [³H]l-Desamino-8-D-Arginine Vasopressin as a Radioligand for Vasopressin V₂-Receptors in Rat Kidney*

Endocrinology, 1988
[3H]l-Desamino-8-D-arginine vasopressin [3H] DDAVP was assessed as a radioligand for vasopressin V2-receptors by studying its membrane-binding characteristics and in vitro autoradiographic localization in rat kidney, a rich source of V2-receptors.
A.J. MARCHINGO, J. M. Abrahams, Elizabeth A. Woodcock, A. Ian Smith, F. A. O. Mendelsohn, C. I. Johnston   +5 more
openalex   +2 more sources

Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists

Bioorganic & Medicinal Chemistry, 2008
The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V(2) receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V(2) receptor agonist. These studies provided the
Issei, Tsukamoto, Hiroyuki, Koshio, Seijiro, Akamatsu, Takahiro, Kuramochi, Chikashi, Saitoh, Takeyuki, Yatsu, Hiroko, Yanai-Inamura, Chika, Kitada, Eisaku, Yamamoto, Shuichi, Sakamoto, Shin-Ichi, Tsukamoto   +10 more
openaire   +2 more sources

[Identification of mutations in the arginine vasopressin receptor 2 gene in congenital nephrogenic diabetes insipidus patients].

Zhonghua yi xue za zhi, 2003
To investigate the mutations of arginine vasopressin receptor 2 (AVPR2) gene in congenital nephrogenic diabetes insipidus (NDI) patients.Genomic DNA was extracted from the blood samples of 7 congenital NDI patients, all males, and 24 of their family members. The 6 fragments of AVPR2 gene were amplified by PCR.
Feng, Gu, Yifan, Shi, Jieying, Deng, Zimeng, Jin   +3 more
openaire   +1 more source

Short‐ and long‐term treatment of dilutional hyponatraemia with satavaptan, a selective arginine vasopressin V₂‐receptor antagonist: the DILIPO study

European Journal of Heart Failure, 2011
AimsArginine vasopressin (AVP) V2 receptor antagonism is a new approach to the management of hyponatraemia in congestive heart failure (CHF). The aim of this study was to investigate the efficacy and safety of satavaptan, an oral AVP V2‐receptor antagonist, in patients with dilutional hyponatraemia.Methods and resultsA total of 118 patients (90 with ...
Aronson, D., Verbalis, J., Mueller, M, Krum, H., DILIPO investigators,   +4 more
openaire   +2 more sources

Position 4 analogues of [deamino-Cys1] arginine vasopressin exhibit striking species differences for human and rat V2/V1b receptor selectivity

Journal of Peptide Science, 2006
Arginine vasopressin (AVP) mediates a wide variety of biological actions by acting on three distinct G-protein coupled receptors, termed V(1a) (vascular), V(1b) (pituitary) and V(2) (renal). It also binds to the oxytocin (OT) receptor. As part of a program aimed at the design of selective agonists for the human V(1b) receptor, we recently reported the ...
Gilles, Guillon, Ana, Pena, Brigitte, Murat, Sylvain, Derick, Miguel, Trueba, Maria A, Ventura, Hazel H, Szeto, Nga, Wo, Stoytcho, Stoev, Ling Ling, Cheng, Maurice, Manning   +10 more
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly