Results 31 to 40 of about 177,245 (312)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Applied Sciences, 2021 Plasma modification of soft polymeric surfaces has many prospects in creating biomedical devices. The deformability of the obtained coatings should be studied, as the usage of such materials implies mechanical loads.
Ilya A. Morozov +6 more
doaj +1 more source
Nature, 1895 THE discovery of the new substance argon, by Lord Rayleigh, has given rise to a difficulty which, it is thought by some, shows that the periodic law of Mendelejeff has not that generality which has been attached to it by chemists during the last few years.
openaire +3 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
The Ionization of Argon and Neon by Neutral Argon Beams [PDF]
Proceedings of the National Academy of Sciences, 1932 As a result of the discovery of Kallmann and Rosen [1,2] that the probability of charge transfer is very great for gas ions moving in a gas of their own molecular or atomic species, the possibility of obtaining an atomic beam of high intensity is at once indicated.
openaire +4 more sources
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Communications Earth & EnvironmentMagma-rich continental rifting and breakup commonly show complex distributions of volcanism, potentially due to both plume and rifting controls. As such, interpreting the main controls on the spatial evolution of magmatism is debated, as is the point at ...
Gianmaria Tortelli +9 more
doaj +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source