Results 31 to 40 of about 555,573 (335)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High Efficiency Detection of Argon Scintillation Light of 128nm Using LAAPDs

, 2005
The possibility of efficient collection and detection of vacuum ultraviolet light as emitted by argon, krypton, and xenon gas is studied. Absolute quantum efficiencies of large area avalanche photodiodes (LAAPDs) are derived at these wavelengths.
Chandrasekharan, R., Knecht, A., Messina, M., Regenfus, C., Rubbia, A.   +4 more
core   +2 more sources

The Effects of Dissolved Methane upon Liquid Argon Scintillation Light [PDF]

, 2013
In this paper we report on measurements of the effects of dissolved methane upon argon scintillation light. We monitor the light yield from an alpha source held 20 cm from a cryogenic photomultiplier tube (PMT) assembly as methane is injected into a high-
Alexander, T., Back, H. O., Collin, G., Conrad, J. M., Greene, A., Jones, B. J. P., Katori, T., Pordes, S., Toups, M.   +8 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Commutating brushes tested in dc motors in dry argon atmospheres [PDF]

, 1970
Test apparatus, procedures, and results are given for dc-motor brushes operating in dry argon.
Bernstein, G. J., Coleman, L. F., Slawecki, M. A.   +2 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Effect of Temperature on the Complexity of Solid Argon System

, 2015
We study the measure of complexity in solid Argon system from the time series data of kinetic energy of single Argon atoms at different equilibrated temperatures.
Barat, P, Dey, S, Giri, A
core   +1 more source

Influence of Environment on Creep Properties of MC2 Single Crystal Superalloy at 1150°C [PDF]

, 2004
In order to reveal the effect of oxidation on thin blade walls, a new machine allowing tests up to 1250°C under controlled atmosphere has been designed.
Andrieu, Eric, Crabos, Fabrice, Dryepondt, Sébastien, Monceau, Daniel, Vernault, Cyril   +4 more
core   +1 more source

INVESTIGATION OF THE ROLE OF LIME UNDER SLAGGING AND INERT-GAS SECONDARY STEEL REFINING

Advanced Engineering Research, 2013
It is shown that the creation of such technologies is caused by the necessity of making standard high-quality steel in composition and temperature. The secondary steel refining provides these conditions and, consequently, the efficient operation of the ...
Denis Anatolyevich Bakhayev, Alexander Ivanovich Kochetov, Alexander Yuryevich Kem, Alexey Alexandrovich Ansimov   +3 more
doaj   +1 more source

Effects of nitrogen gas flushing in comparison with argon on rumen fermentation characteristics in in vitro studies

Journal of Animal Science and Technology, 2020
In rumen in vitro experiments, although nitrogen gas (N2) flushing has been widely used, its effects on rumen fermentation characteristics are not clearly determined.
KiYeon Park, HongGu Lee
doaj   +1 more source