Results 31 to 40 of about 147,336 (255)
The Ionization of Argon and Neon by Neutral Argon Beams [PDF]
Proceedings of the National Academy of Sciences, 1932 As a result of the discovery of Kallmann and Rosen [1,2] that the probability of charge transfer is very great for gas ions moving in a gas of their own molecular or atomic species, the possibility of obtaining an atomic beam of high intensity is at once indicated.
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
ORGANIZATION OF PROTECTION MECHANISMS FOR CLOUD STORAGE SERVICES
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 Providing effective security mechanisms is an important requirement to any secure cloud solution. In this sense, it's proposed to use a hybrid approach to cloud security that includes both warning and detection mechanisms in order to minimize the ...
T. .. Galibus +7 more
doaj
INVESTIGATION OF THE ROLE OF LIME UNDER SLAGGING AND INERT-GAS SECONDARY STEEL REFINING
Advanced Engineering Research, 2013 It is shown that the creation of such technologies is caused by the necessity of making standard high-quality steel in composition and temperature. The secondary steel refining provides these conditions and, consequently, the efficient operation of the ...
Denis Anatolyevich Bakhayev +3 more
doaj +1 more source
Journal of Animal Science and Technology, 2020 In rumen in vitro experiments, although nitrogen gas (N2) flushing has been widely used, its effects on rumen fermentation characteristics are not clearly determined.
KiYeon Park, HongGu Lee
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source