Results 41 to 50 of about 177,245 (312)

ORGANIZATION OF PROTECTION MECHANISMS FOR CLOUD STORAGE SERVICES

Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2019
Providing effective security mechanisms is an important requirement to any secure cloud solution. In this sense, it's proposed to use a hybrid approach to cloud security that includes both warning and detection mechanisms in order to minimize the ...
T. .. Galibus, V. .. Krasnoproshin, P. V. Thiago, T. DE. Rafael, P. C. João, P. DE. Edison, Z. Anton, H. E. Vissia   +7 more
doaj  

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

A pulse of mid-Pleistocene rift volcanism in Ethiopia at the dawn of modern humans

Nature Communications, 2016
Past volcanic eruptions along the densely populated Ethiopian Rift valley remain poorly constrained despite the present day hazard. Hutchison et al.
William Hutchison, Raffaella Fusillo, David M. Pyle, Tamsin A. Mather, Jon D. Blundy, Juliet Biggs, Gezahegn Yirgu, Benjamin E. Cohen, Richard A. Brooker, Dan N. Barfod, Andrew T. Calvert   +10 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Autonomous observations of biogenic N2 in the Eastern Tropical North Pacific using profiling floats equipped with gas tension devices

Frontiers in Marine Science, 2023
Oxygen Deficient Zones (ODZs) of the world’s oceans represent a relatively small fraction of the ocean by volume (<0.05% for suboxic and<5% for hypoxic) yet are receiving increased attention by experimentalists and modelers due to their importance ...
Craig L. McNeil, Eric A. D’Asaro, Mark A. Altabet, Roberta C. Hamme, Emilio Garcia-Robledo   +4 more
doaj   +1 more source

The role of argon in stroke [PDF]

Medical Gas Research, 2018
Stroke, also known as "cerebrovascular accident", is an acute cerebrovascular disease that is caused by a sudden rupture of blood vessels in the brain or obstruction of the blood supply by blockage of blood vessels, thus including hemorrhagic and ischemic strokes.
Jin-Quan Li, Zhong Wang, Xiang Li, Gang Chen, Zhuwei Zhang   +4 more
openaire   +3 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Carrier properties of B atomic-layer-doped Si films grown by ECR Ar plasma-enhanced CVD without substrate heating

Science and Technology of Advanced Materials, 2017
The atomic-layer (AL) doping technique in epitaxy has attracted attention as a low-resistive ultrathin semiconductor film as well as a two-dimensional (2-D) carrier transport system.
Masao Sakuraba, Katsutoshi Sugawara, Takayuki Nosaka, Hisanao Akima, Shigeo Sato   +4 more
doaj   +1 more source

Effects of nitrogen gas flushing in comparison with argon on rumen fermentation characteristics in in vitro studies

Journal of Animal Science and Technology, 2020
In rumen in vitro experiments, although nitrogen gas (N2) flushing has been widely used, its effects on rumen fermentation characteristics are not clearly determined.
KiYeon Park, HongGu Lee
doaj   +1 more source