Results 91 to 100 of about 3,932,970 (283)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Michael A. Gilbert: Not arguing logically is not illogical: Other ways of communicating arguments

Argumentation et Analyse du Discours
Michael A. Gilbert has contributed significantly to the field of contemporary Argumentation Theory. Most notable are his multi-modal theory of argumentation and coalescent argumentation, models of argument that he developed to address how interlocutors ...
Michael A. Gilbert, Linda Carozza
doaj   +1 more source

Arguing satisfaction of security requirements [PDF]

, 2006
This chapter presents a process for security requirements elicitation and analysis, based around the construction of a satisfaction argument for the security of a system. The process starts with the enumeration of security goals based on assets in the
Haley, Charles B., Laney, Robin, Moffett, Jonathan D., Nuseibeh, Bashar   +3 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Decisiva y postrera pugna argumentativa en La última batalla y final congoja con que aflige el demonio al hombre, de Jerónimo de los Ríos Torquemada

Atalaya, 2019
We study here a dialogic ars moriendi that shows the battle between the Devil and a dying man. In order to introduce the analysis of this dialogue, the origins of the artes moriendi are shown first, to explain then the reception and transmission of these
Germán Redondo Pérez
doaj   +1 more source

Beyond Argument [PDF]

, 2018
Accounts of deep disagreements can generally be categorized as optimistic or pessimistic. Pessimistic interpretations insist that the depth of deep disagreements precludes the possibility of rational resolution altogether, while optimistic variations ...
Wang, Connie
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Le pathos mis à contribution dans les discours à grande circulation

Corela, 2016
In this study, using a theoretical framework for discourse analysis, I start off a reflection that lies at the intersection of semantics, pragmatics and rhetoric, in this discursive space where utterances present cultural patterns with high recurrence ...
Danielle Forget
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Wbudowane pozycje argumentowe a intensjonalna zupełność propozycji

Slavia Meridionalis, 2015
Built in argument positions and the propositions intensional completeness The paper discusses issues concerning the potential influence of built in argument positions on the propositions intensional completeness.
Jakub Banasiak
doaj   +1 more source