Results 111 to 120 of about 3,932,970 (283)
Evaluating arguments and making meta-arguments
Informal Logic, 2001 This paper explores the outlines of a framework for evaluating arguments. Among the factors to take into account are the strength of the arguers' inferences, the level of their engagement with objections raised by other interlocutors, and their ...
Daniel H. Cohen
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Philosophy, 1959 Sometimes we draw conclusions about a thing's existence or its value by considering what are thought to be its consequences. I shall say that an argument is pragmatic when it consists in estimating an action, or any event, or a rule, or whatever it may be, in terms of its favourable or unfavourable consequences; what happens in such cases is that all ...
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The “Positive Argument” for Constructive Empiricism and Inference to the Best Explanation [PDF]
, 2018 In this paper, I argue that the “positive argument” for Constructive Empiricism (CE), according to which CE “makes better sense of science, and of scientific activity, than realism does” (van Fraassen 1980, 73), is an Inference to the Best Explanation ...
Mizrahi, Moti
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Opinion Essay as Example of Discourse Analysis: Rhetorical Assessment
Revista de Lenguas para Fines Específicos, 2015 The argumentative class of texts possesses a certain structure that allows the addressee to recognise the possible controversy of the ideas posed in it, be it for the persuasion of some conflicting view or the mere reflection on what has been uttered. In
Margarita Esther Sánchez Cuervo
doaj
Multi-argument classification for semantic role labeling [PDF]
, 2008 This paper describes a Multi-Argument Classification (MAC) approach to Semantic Role Labeling. The goal is to exploit dependencies between semantic roles by simultaneously classifying all arguments as a pattern.
Lin, Chi-San Althon, Smith, Tony C.
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