Results 101 to 110 of about 140,508 (259)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Action Nominalizations in Business English: A Corpus Study [PDF]

Ovidius University Annals: Economic Sciences Series
Action nominalizations are employed in business English to attain a higher degree of condensation, abstraction, and accuracy. This paper reports on a corpus-based study of the actual usage patterns of -tion nominals in business news.
Camelia Bejan
doaj  

Is FrameNet usage-based? Predicting frame element coreness with information theory and gradient boosting

Language and Cognition
The FrameNet project is a large-scale frame-semantic database with a seemingly usage-based core: It draws on 200,000 annotated sentences from representative corpora and offers the most comprehensive description of semantic valency patterns in English to ...
Vladimir Buskin
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Argument structure and semantic explanation of the verb nggawa ‘to bring’ in Javanese: a natural semantic metalanguage approach

Cogent Arts & Humanities
The Javanese language has many verbs that describe how to carry inanimate objects, living things, humans, or animals. One of the most common words is nggawa, which is glossed here as ‘to bring’.
Mulyono Mulyono, Arie Yuanita, Mochamad Bayu Firmansyah, Dianita Indrawati, Siti Rumilah, Anggoro Abiyyu Ristio Cahyo, Molion Syahputra Mulya   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Argument Structure

, 2013
The term “argument structure” is used to refer to the lexical representation of argument-taking lexical items—typically verbs, but also nouns (especially nominalizations), adjectives, and even prepositions—that specifies sufficient information about these items’ arguments to allow their syntactic realization to be determined.
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Freeman's Syntactic Criterion for Linkage

Informal Logic, 2015
Freeman’s syntactic criterion for linked argument structure (Freeman 2011) is often readily applicable, captures intuitively linked structures, and implies that refuting a single premiss of a linked argument suffices to refute the argument.
David Hitchcock
doaj