Results 81 to 90 of about 7,433,455 (293)

On the argument-adjunct distinction in the Polish “Semantic Syntax” tradition

Cognitive Studies | Études cognitives, 2017
On the argument-adjunct distinction in the Polish Semantic Syntax tradition The aim of this paper is to examine the understanding of the Argument-Adjunct Distinction within the Polish Semantic Syntax (SS) tradition, associated with the name of ...
Adam Przepiórkowski
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Lexical–Syntactic Classes of Adjectives in Copular Sentences across Spanish Varieties: The Innovative Use of Estar

Languages
This paper aims to provide a clearer understanding of the structure known in the literature as the innovative use of estar, illustrated in sentences like Luego salgo/voy a visitar usuarios que están muy morosos [Medellín, Colombia; Preseea] (“Today I am ...
Silvia Gumiel-Molina, Norberto Moreno-Quibén, Isabel Pérez-Jiménez   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Third Route to the Doomsday Argument [PDF]

, 2002
In this paper, I present a solution to the Doomsday argument based on a third type of solution, by contrast to on the one hand, the Carter-Leslie view and on the other hand, the Eckhardt et al. analysis.
Paul Franceschi, Franceschi, Paul
core  

Dispositional middle constructions with accusative objects in Slovenian

Glossa
This paper provides a study of an impersonal type of dispositional middle construction that appears in Slovenian. This impersonal construction atypically contains an undemoted thematic external argument in syntax, but nevertheless ascribes a disposition ...
Jakob Lenardič
doaj   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source