Results 81 to 90 of about 15,656,567 (305)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Latin datives with prefixed verbs and beyond: A view from the theory of applicatives

Catalan Journal of Linguistics, 2017
I discuss the syntax and semantics of dative DPs with a spatial (Ground) interpretation, focusing on those dependent on prefixed verbs, in Early and Classical Latin.
Víctor Acedo-Matellán
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The Neron-Severi group of a proper seminormal complex variety

, 2008
We prove a Lefschetz (1,1)-Theorem for proper seminormal varieties over the complex numbers. The proof is a non-trivial geometric argument applied to the isogeny class of the Lefschetz 1-motive associated to the mixed Hodge structure on H^2.Comment: 16 ...
Andreas Rosenschon, H. Esnault, J. Biswas, J. Kollár, J.-F. Boutot, L. Barbieri-Viale, L. Barbieri-Viale, L. Barbieri-Viale, Luca Barbieri-Viale, N. Ramachandran, P. Deligne, P. Deligne, R. Hartshorne, R. Swan, S. Greco, S. Lefschetz, V. Srinivas   +16 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Lexical–Syntactic Classes of Adjectives in Copular Sentences across Spanish Varieties: The Innovative Use of Estar

Languages
This paper aims to provide a clearer understanding of the structure known in the literature as the innovative use of estar, illustrated in sentences like Luego salgo/voy a visitar usuarios que están muy morosos [Medellín, Colombia; Preseea] (“Today I am ...
Silvia Gumiel-Molina, Norberto Moreno-Quibén, Isabel Pérez-Jiménez   +2 more
doaj   +1 more source

Argument Structure of Classifier Predicates: Canonical and Non-canonical Mappings in Four Sign Languages

Open Linguistics, 2019
We analyze argument structure of whole-entity and handling classifier predicates in four sign languages (Russian Sign Language, Sign Language of the Netherlands, German Sign Language, and Kata Kolok) using parallel datasets (retellings of the Canary Row ...
Kimmelman Vadim, de Lint Vanja, de Vos Connie, Oomen Marloes, Pfau Roland, Vink Lianne, Aboh Enoch O.   +6 more
doaj   +1 more source

Complex predicates: an LFG+glue analysis

Journal of Language Modelling, 2016
In this paper I discuss weaknesses in the traditional LFG account of complex predicates and in the XLE implementation of the same. I argue that the concept of predicate composition in general, and the mechanisms required to achieve it, are problematic ...
John J. Lowe
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source