Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger +5 more
wiley +1 more source
Examining Discursive Features in Crowdsourced Deliberation: Idea Generation through Elaboration. [PDF]
Aitamurto T, Royal P, Saldivar J.
europepmc +1 more source
Molecular Bridges for 2D Nanomaterials
Molecular cross‐linking provides a versatile strategy to engineer interfaces in 2D materials. By tuning the linker backbone, binding mode, and interflake spacing, molecular bridges can regulate charge transport, mechanical integrity, chemical functionality, and processing.
Yudhajit Bhattacharjee +3 more
wiley +1 more source
Measuring complex constructs in large-scale text with computational social mixed methods. [PDF]
Herderich A +5 more
europepmc +1 more source
Ultra‐Thin Tow‐Based Discontinuous Composites—Material Overview and Aspirations
Tow‐based discontinuous composites made from ultra‐thin tapes offer outstanding in‐plane mechanical properties. This material, inspired by Nacre, has high volume fraction of tapes exceeding 90 % and allows for quasi‐isotropic material plates less than 100 micrometer in thickness.
Ioannis Katsivalis +8 more
wiley +1 more source
Replication and replicability as epistemic opportunity for the humanities: reflections on a Rembrandt attribution case study. [PDF]
Rulkens CCS +3 more
europepmc +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
(Mis)representing the Opposition and Rhetorical Success: Experimental Evidence on Faithful and Inaccurate Reformulations. [PDF]
Younis R.
europepmc +1 more source
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu +3 more
wiley +1 more source
Will the widespread use of large language models in scientific writing undermine scientists' critical thinking? [PDF]
Bietti LM, Bangerter A.
europepmc +1 more source

