Results 41 to 50 of about 73,546 (295)
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Casinos and recreational spaces for music: the case of the city of Soria (1848-1936)
Studia Historica: Historia Contemporánea, 2018 The associationist models are an expanding fact since the second half of the nineteenth century, with cultural identity in the so-called casinos, recreational circles and athenaeums.
José Ignacio PALACIOS SANZ +1 more
doaj
Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies
The Journal of Prevention of Alzheimer's DiseaseAmyloid related imaging abnormalities (ARIA) are the most significant risk associated with the use of anti-amyloid monoclonal antibodies (MAB) for Alzheimer’s disease (AD).
Marc W. Haut +13 more
doaj +1 more source
Advanced Science, EarlyView.In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han +10 more
wiley +1 more source
Lecanemab over a two-year duration: Key insights from a regional specialty medical center
The Journal of Prevention of Alzheimer's DiseaseBackground and objectives: The anti-amyloid monoclonal antibody lecanemab (Leqembi®) treats patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer’s disease (AD).
Lisa B.E. Shields +14 more
doaj +1 more source
Revista Alergia México, 2019 The vast majority of patients with allergic rhinitis (AR) do not receive the proper management which is recommended by the guidelines, but they frequently self-medicate.
Désirée Larenas-Linnemann +45 more
doaj +1 more source
Il risparmio di energia nella produzione di aria compressa [PDF]
, 2022 Il progetto si propone di analizzare i sistemi di aria compressa nel territorio veneto per far emergere i margini di miglioramento del consumo di ...
Ferraro, Luca
core
Farmers' Preferences for Gene Editing Crops and Influencing Factors
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Gene editing (GE) is gaining momentum worldwide, but limited data on UK farmers' preferences hinders our understanding of its potential impact amid deregulation debates. Based on a survey of 200 English arable farmers, we employ a Latent Class Analysis and Multinomial Logit regressions to investigate current preferences for GE crops.
Bertolozzi‐Caredio Daniele +1 more
wiley +1 more source
Angewandte Chemie, EarlyView.Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene +5 more
wiley +2 more sources
MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer
Annals of Gastroenterological Surgery, EarlyView.Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li +5 more
wiley +1 more source