Results 51 to 60 of about 47,373 (236)

Utilizing RxNorm to Support Practical Computing Applications: Capturing Medication History in Live Electronic Health Records

, 2012
RxNorm was utilized as the basis for direct-capture of medication history data in a live EHR system deployed in a large, multi-state outpatient behavioral healthcare provider in the United States serving over 75,000 distinct patients each year across 130
Bodenreider, Bodenreider, Casey C. Bennett, Cover, Fung, Henkel, Hernandez, Hoffer, Kobayashi, Levin, Nelson, O’Neill, Palchuk, Pathak, Richesson, Ruch, Russell, Shannon, Szegedi, Wade, Zeng   +20 more
core   +1 more source

Tourette Syndrome Research Highlights from 2017 [version 1; referees: 3 approved] [PDF]

, 2018
This is the fourth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2017 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting.
Black, Kevin J, Hartmann, Andreas, Worbe, Yulia   +2 more
core   +2 more sources

Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis

Frontiers in Pharmacology, 2020
Background: Antipsychotics modulate expression of inflammatory cytokines and inducible inflammatory enzymes. Elopiprazole (a phenylpiperazine antipsychotic drug in phase 1) has been characterized as a therapeutic drug to treat SARS-CoV-2 infection in a ...
B. Crespo-Facorro, M. Ruíz-Veguilla, J. Vázquez-Bourgon, Ana C. Sánchez-Hidalgo, Nathalia Garrido-Torres, J. Cisneros, Carlos Prieto, Jesus Sainz   +7 more
semanticscholar   +1 more source

Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database [PDF]

, 2013
Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US ...
A Bate, A Clarke, A Pariente, AK Chung, Ariola Koci, B Darpo, BJ Drew, C Meyer-Massetti, DM Roden, DW Hough, E Poluzzi, E Poluzzi, E Poluzzi, E Raschi, E Raschi, Edoardo Spina, Elijah R. Behr, Elisabetta Poluzzi, Emanuel Raschi, EP Puijenbroek van, ER Behr, F Ponti De, F Ponti De, F Rani, Fabrizio De Ponti, GC Alexander, GK Isbister, H Verdoux, J Nielsen, J Papay, K Jolly, K Titier, LC Wittkampf, LS Schneider, Miriam Sturkenboom, NP Tatonetti, P Kannankeril, P Manu, P Vigneault, RC Owens Jr, RR Shah, S Dhillon, S Hennessy, S Kongsamut, S Leucht, SM Straus, Ugo Moretti, W Crumb, W Crumb, WA Ray, WA Ray, WJ Crumb Jr, WP Stephenson, Y Suzuki   +53 more
core   +4 more sources

Optimization of Processing Parameters of Nanoemulsion Containing Aripiprazole Using Response Surface Methodology

International Journal of Nanomedicine, 2020
Background Aripiprazole, which is a quinolinone derivative, has been widely used to treat schizophrenia, major depressive disorder, and bipolar disorder.
Wan Sarah Samiun, Siti Efliza Ashari, Norazlinaliza Salim, Syahida Ahmad   +3 more
semanticscholar   +1 more source

Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats. [PDF]

PLoS ONE, 2015
Aripiprazole is a wide-used antipsychotic drug with therapeutic effects on both positive and negative symptoms of schizophrenia, and reduced side-effects.
Bo Pan, Jiezhong Chen, Jiamei Lian, Xu-Feng Huang, Chao Deng   +4 more
doaj   +1 more source

Pharmacological interventions for challenging behaviour in children with intellectual disabilities: a systematic review and meta-analysis [PDF]

, 2015
Background Psychotropic medications are frequently used to treat challenging behaviour in children with intellectual disabilities, despite a lack of evidence for their efficacy.
Harrison, Bronwyn, Hassiotis, Angela, McQuire, Cheryl, Pilling, Steve   +3 more
core   +4 more sources

Drug–drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics

Frontiers in Psychiatry
BackgroundThe present study aimed to investigate the drug–drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics.Research design and methodsA total of 119 patients with ...
Cun Zhang, Lei Jiang, Lei Jiang, Ke Hu, Yi-Jia Zhang, Yi-Jia Zhang, Jing Han, Jing Han, Jin Chen, Jin Chen, Bulubu, Bulubu, Boling Dong, Boling Dong, Hao-Zhe Shi, Hao-Zhe Shi, Su-Mei He, Ting-Ting Yu, Xiao Chen, Dong-Dong Wang   +19 more
doaj   +1 more source

Dopamine receptor D2 activation suppresses the radiosensitizing effect of aripiprazole via activation of AMPK

FEBS Open Bio, 2019
Drug repositioning has garnered attention as an alternative strategy to the discovery and development of novel anticancer drug candidates. In this study, we screened 321 FDA‐approved drugs against nonirradiated and irradiated MCF‐7 cells, revealing that ...
Hyounji Lee, Seongman Kang, Jong Kyung Sonn, Young‐Bin Lim   +3 more
doaj   +1 more source

The role of kinetic context in apparent biased agonism at GPCRs [PDF]

, 2016
Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific drugs that avoid on-target side effects. This mechanism is usually
A Akinc, A Hill, A Lahti, A Saulière, AW Kahsai, B Masri, C Sampaio, D Guo, D Möller, D Sykes, D Unett, D Wacker, DA Sykes, DR Sibley, EJ Whalen, ET van der Westhuizen, F Pedregosa, GJ Kilpatrick, H Abdi, H Motulsky, H Sheth, J Allen, J McPherson, J Shonberg, J Shonberg, JD Urban, JD Urban, JD Violin, JE Murphy, JJ Liu, JP Overington, JP Vilardaga, JR Lane, JW Black, JW Wisler, KV Andreassen, L Carboni, L Gazi, M Griffin, M Szabo, M Vilums, MT Drake, N Tschammer, O Agid, P Molinari, P Tummino, R Irannejad, R Rahmeh, S Ahn, S Durgam, S Ferrandon, S Galandrin, S Nijmeijer, S Rajagopal, SJ Charlton, SK Shenoy, T Kenakin, T Kenakin, T Kenakin, T Warne, W Stallaert, X-T Chen, Y Cheng   +62 more
core   +1 more source