Clinical Pharmacology in Drug Development, EarlyView.Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens +2 more
wiley +1 more source
The Language of Numbers: Reading Comprehension and Applied Math Problem-Solving. [PDF]
Behav Sci (Basel)Sury D, Pilchin L.
europepmc +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj +6 more
wiley +1 more source
Heart rate variability reveals graded task difficulty effects and sensitization dynamics in anticipatory psychological stress via time-domain analysis. [PDF]
J Physiol AnthropolJian Z, Huang J, Shi F, Shimomura Y.
europepmc +1 more source
ESG Performance Evolution in Retail: A Systematic Review and Meta‐Analysis
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Environmental, social, and governance (ESG) practices have transformed from peripheral corporate social responsibility initiatives into core strategic imperatives in retail. Despite growing interest, the literature remains fragmented across disciplines and geographic contexts, with no comprehensive sector‐specific analysis examining the ...
Jiyeon Kim, Wooyoung Yang
wiley +1 more source
Ceralasertib, an ATR kinase inhibitor, as monotherapy in Japanese patients with advanced solid malignancies: Results from a phase 1 study. [PDF]
Invest New DrugsKuboki Y +15 more
europepmc +1 more source
A New Strategy to Design Reconfigurable Rivest–Shamir–Adleman (RSA) Accelerators
International Journal of Circuit Theory and Applications, EarlyView.A reconfigurable FPGA‐based RSA accelerator is proposed using compression‐based modular multipliers combined with pseudomoduli arithmetic. The approach maps modular exponentiation to low‐cost arithmetic domains and applies a correction stage, achieving significant improvements in delay, operating frequency, and delay–area efficiency compared with ...
Augusto C. B. Vassoler +4 more
wiley +1 more source
Determination of nutritional and mineral constituents and physical characteristics of Yubka kidney bean seeds from Talas region of Kyrgyzstan. [PDF]
Sci RepTorun A, Paksoy M, Kayahan N.
europepmc +1 more source
Microscopic time‐dependent mechanical behavior of shale derived from nanoindentation
Deep Underground Science and Engineering, EarlyView.This study conducted grid nanoindentation creep tests to systematically analyze the microscopic creep behaviors of shale. Based on the analysis of creep strain rate sensitivity, the primary mechanism of microscopic creep in shale was found to be the extension and closure of microcracks.
Cunbao Li +4 more
wiley +1 more source
Efficacy of oral afoxolaner and a combination of afoxolaner, moxidectin, and pyrantel against Amblyomma maculatum in dogs. [PDF]
Parasit VectorsPrullage J +5 more
europepmc +1 more source