Results 1 to 10 of about 2,827 (178)

Unraveling the Genetic Links Between Polycystic Kidney Disease and Hypertension Through ARL13B [PDF]

International Journal of Nephrology and Renovascular Disease
Juan Chen,1,* Lei Song,2,* Shuqin Mei,1,* Jing Huang,3 Lili Fu,1 Chenchen Zhou,1 Xiaohua Hu,1 Liming Zhang,1 Cheng Xue,1,3 Zhiguo Mao1 1Kidney Institute, Division of Nephrology, Shanghai Changzheng Hospital, Second Military ...
Chen J, Song L, Mei S, Huang J, Fu L, Zhou C, Hu X, Zhang L, Xue C, Mao Z   +9 more
doaj   +6 more sources

Loss of a primary cilia protein ARL13B promotes TGFβ-1 induced EMT of RPE in proliferative vitreoretinopathy via increasing Smad3 expression [PDF]

Frontiers in Cell and Developmental Biology
BackgroundProliferative vitreoretinopathy (PVR) is a major complication of rhegmatogenous retinal detachment. Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) plays a central role in PVR pathogenesis.
Wenjun Sui, Wenjun Sui, Xinqi Ma, Xinqi Ma, Xinqi Ma, Yajun Gong, Yajun Gong, Kairui Qiu, Kairui Qiu, Miner Yuan, Miner Yuan, Keli Mao, Keli Mao, Keli Mao, Xiaobing Qian, Xiaobing Qian, Jieting Zeng, Jieting Zeng, Yujie Li, Yujie Li, Bingsheng Lou, Bingsheng Lou, Xiaofeng Lin, Xiaofeng Lin, Xiaolai Zhou, Xiaolai Zhou   +25 more
doaj   +3 more sources

Knocking out ARL13B completely abolishes primary ciliogenesis in cell lines [PDF]

Scientific Reports
Small G protein ARL13B localizes to the cilium and plays essential roles in cilium biogenesis, organization, trafficking, and signaling. Here, we established multiple ARL13B knockout cell lines using the CRISPR/Cas9 system.
Divyanshu Mahajan, Hui Min Chia, Lei Lu
doaj   +3 more sources

ARL13B regulates Sonic hedgehog signaling from outside primary cilia [PDF]

eLife, 2020
ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of
Eduardo D Gigante, Megan R Taylor, Anna A Ivanova, Richard A Kahn, Tamara Caspary   +4 more
doaj   +4 more sources

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules [PDF]

Nature Communications, 2018
The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be
Kai He, Xiaoyu Ma, Tao Xu, Yan Li, Allen Hodge, Qing Zhang, Julia Torline, Yan Huang, Jian Zhao, Kun Ling, Jinghua Hu   +10 more
doaj   +4 more sources

Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain [PDF]

Cells
Primary cilia are hair-like structures found on nearly all mammalian cell types, including cells in the developing and adult brain. A diverse set of receptors and signaling proteins localize within cilia to regulate many physiological and developmental ...
Katlyn K. Brewer, Kathryn M. Brewer, Tiffany T. Terry, Tamara Caspary, Christian Vaisse, Nicolas F. Berbari   +5 more
doaj   +5 more sources

ARL13B controls male reproductive tract physiology through primary and Motile Cilia

Communications Biology
ARL13B is a small regulatory GTPase that controls ciliary membrane composition in both motile cilia and non-motile primary cilia. In this study, we investigated the role of ARL13B in the efferent ductules, tubules of the male reproductive tract essential
Céline Augière, Gabriel Campolina-Silva, Aaran Vijayakumaran, Odara Medagedara, Camille Lavoie-Ouellet, Charles Joly Beauparlant, Arnaud Droit, Ferran Barrachina, Kiera Ottino, Maria Agustina Battistone, Kedar Narayan, Rex Hess, Vito Mennella, Clémence Belleannée   +13 more
doaj   +4 more sources

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia [PDF]

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +2 more sources

Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity [PDF]

Life
Spaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased ...
Seung Hyun Bang, Soyoung Hwang, Seon Young Choi, Hyun Joo Kim, Joo Hyung Kim, Sung Ho Lee, Jin Woo Lee, Kuk Hui Son   +7 more
doaj   +2 more sources

Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols [PDF]

Frontiers in Cell and Developmental Biology
IntroductionCiliopathies are a group of human Mendelian disorders caused by dysfunction of primary cilia, small quasi-ubiquitous sensory organelles. Patients suffering from ciliopathies often display prominent neurodevelopmental phenotypes, underscoring ...
Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu   +18 more
doaj   +2 more sources