The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance [PDF]
Cell Reports, 2019 Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the ...
Julien Ferent +2 more
exaly +7 more sources
The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]
Cell Adhesion and Migration, 2016 Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Michal Pruski +2 more
exaly +11 more sources
Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain [PDF]
CellsPrimary cilia are hair-like structures found on nearly all mammalian cell types, including cells in the developing and adult brain. A diverse set of receptors and signaling proteins localize within cilia to regulate many physiological and developmental ...
Katlyn K. Brewer +5 more
doaj +6 more sources
Arl13b regulates endocytic recycling traffic [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2012 Intracellular recycling pathways play critical roles in internalizing membrane and fluid phase cargo and in balancing the inflow and outflow of membrane and cell surface molecules. To identify proteins involved in the regulation of endocytic recycling, we used an shRNA trafficking library and screened for changes in the surface expression of CD1a ...
Duarte C Barral +2 more
exaly +5 more sources
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane [PDF]
Biology Open, 2021 INPP5E, a phosphoinositide 5-phosphatase, localizes on the ciliary membrane via its C-terminal prenyl moiety, and maintains the distinct ciliary phosphoinositide composition.
Sayaka Fujisawa +5 more
doaj +7 more sources
Arl13b interferes with α-tubulin acetylation [PDF]
Cilia, 2015 publishersversionpublishe
C Seixas +3 more
core +5 more sources
Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome [PDF]
American Journal of Human Genetics, 2008 Joubert syndrome (JS) and related disorders are a group of autosomal-recessive conditions sharing the "molar tooth sign" on axial brain MRI, together with cerebellar vermis hypoplasia, ataxia, and psychomotor delay. JS is suggested to be a disorder of cilia function and is part of a spectrum of disorders involving retinal, renal, digital, oral, hepatic,
Vincent Cantagrel +2 more
exaly +12 more sources
Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain [PDF]
PLoS Genetics, 2013 Cilia are microtubule-based cell appendages, serving motility, chemo-/mechano-/photo- sensation, and developmental signaling functions. Cilia are comprised of distinct structural and functional subregions including the basal body, transition zone (TZ ...
Sebiha Cevik +2 more
exaly +4 more sources
ARL13B regulates Sonic hedgehog signaling from outside primary cilia [PDF]
eLife, 2020 ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of
Eduardo D Gigante +4 more
doaj +6 more sources
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans [PDF]
Journal of Cell Biology, 2010 The small ciliary G protein Arl13b is required for cilium biogenesis and sonic hedgehog signaling and is mutated in patients with Joubert syndrome (JS).
Blacque, O.E. +9 more
core +11 more sources