Results 141 to 150 of about 4,305 (234)

Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF)

Journal of Biological Chemistry, 2017
Primary cilia play central roles in signaling during metazoan development. Several key regulators of ciliogenesis and ciliary signaling are mutated in humans, resulting in a number of ciliopathies, including Joubert syndrome (JS).
A. A. Ivanova, T. Caspary, N. Seyfried, D. Duong, A. West, Zhiyong Liu, R. Kahn   +6 more
semanticscholar   +1 more source

Abstract 81: ARL13B interacts with IMPDH2 to modulate purine synthesis and temozolomide resistance in glioblastoma

Cancer Research, 2019
Abstract Glioblastoma, a universally lethal primary brain tumor, harnesses cellular plasticity to drive therapeutic adaptation. Critical factors in developing this plasticity are histone modifiers such as Polycomb Repressor Complex 2 protein EZH2.
Eunüs S. Ali, Cheol Park, Issam Ben-Sahra, Atique Ahmed, Jack Shireman, Miranda R. Saathoff   +5 more
openaire   +2 more sources

Joubert syndrome: report of 11 cases

The Turkish Journal of Pediatrics, 2012
Joubert syndrome (JS) is an autosomal recessive condition characterized by hypotonia, ataxia, psychomotor delay, and variable occurrence of oculomotor apraxia and neonatal breathing abnormalities.
Faruk İncecik, M Özlem Hergüner, Şakir Altunbaşak, Joseph G Gleeson   +3 more
doaj  

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments [PDF]

, 2018
Tanya L. Dilan, Abigail R. Moye, Ezequiel M. Salido, Thamaraiselvi Saravanan, Saravanan Kolandaivelu, Andrew F.X. Goldberg, Visvanathan Ramamurthy   +6 more
openalex   +1 more source

Supplemental Figures from Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway

, 2023
Jia Shao, Linlin Xu, Limin Chen, Quqin Lu, Xinsheng Xie, Wei Shi, Huanting Xiong, Chao Shi, Xuan Huang, Jinhong Mei, Hai Rao, Hua Lu, Nonghua Lü, Shiwen Luo   +13 more
openalex   +2 more sources

Autophagy regulates ionizing radiation-induced primary ciliogenesis in glioblastoma cells

Fushe yanjiu yu fushe gongyi xuebao
The role of autophagy in ionizing radiation (IR)-induced primary ciliogenesis in glioblastoma cells was explored. M059K and M059J cells underwent treatment with either 10 Gy of X-rays or serum starvation (SS) for three days.
JIN Liangliang, YU Feifei, ZHANG Tongshan, HE Jinpeng, YANG Yanli   +4 more
doaj   +1 more source

Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 3

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: We present prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome (sSMC) derived from chromosome 3.
Chih-Ping Chen, Tsang-Ming Ko, Chen-Yu Chen, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Fang-Tzu Wu, Chen-Wen Pan, Wayseen Wang   +8 more
doaj  

TMEM67 is required for the gating function of the transition zone that controls entry of membrane-associated proteins ARL13B and INPP5E into primary cilia.

Biochemical and Biophysical Research Communications - BBRC, 2022
Zhu Yinsheng, K. Miyoshi, Yu Qin, Yuuki Fujiwara, Takeshi Yoshimura, T. Katayama   +5 more
semanticscholar   +1 more source

Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.

Biochemical Pharmacology, 2022
K. Thirugnanam, S. Prabhudesai, Emma Van Why, Amy Pan, Ankan Gupta, Koji L. Foreman, R. Zennadi, K. Rarick, S. Nauli, Sean P. Palecek, R. Ramchandran   +10 more
semanticscholar   +1 more source

Hedgehog signaling is non-cell autonomously activated in the cystic kidney of Arl13b mutant mice

bioRxiv, 2022
C. Hsieh, S. Jerman, Zhaoxia Sun
semanticscholar   +1 more source