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Dysregulated <i>SASS6</i> expression promotes increased ciliogenesis and cell invasion phenotypes. [PDF]
Hargreaves E +19 more
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A type of pancreatic cancer cells form cell clusters from a solitary condition in a primary ciliogenesis-dependent manner. [PDF]
Shirakawa K +6 more
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Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts
Tissue and Cell, 2023Primary cilia are microtubule-based organelles presenting on the surface of most postmitotic mammalian cells. As being signaling hubs and sensory organelles, primary cilia can respond to mechanical and chemical stimuli from the extracellular environment.
Tingting, Lin, Yao, Sun
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ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling
Neuro-Oncology, 2022Abstract Background Tumor angiogenesis is essential for solid tumor progression, invasion and metastasis. The aim of this study was to identify potential signaling pathways involved in tumor angiogenesis.
Limin Chen +12 more
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PREreview of "Ciliary ARL13B prevents obesity in mice"
2023This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/8308506. This review reflects comments and contributions from Femi Arogundade, Elena Sena, Luciana Gallo & Olakunle Jaiyesimi. Review synthesized by Jonny Coates.
Luciana Gallo +3 more
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A novel Cre‐inducible knock‐in ARL13B‐tRFP fusion cilium reporter
genesis, 2017SummaryCilia play a major role in the regulation of numerous signaling pathways and are essential for embryonic development. Mutations in genes affecting ciliary function can cause a variety of diseases in humans summarized as ciliopathies. To facilitate the detection and visualization of cilia in a temporal and spatial manner in mouse tissues, we ...
Felizitas Schmitz +4 more
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Arl13b controls basal cell stemness properties and Hedgehog signaling in the mouse epididymis
Cellular and Molecular Life Sciences, 2022Epithelial cells orchestrate a series of intercellular signaling events in response to tissue damage. While the epididymis is composed of a pseudostratified epithelium that controls the acquisition of male fertility, the maintenance of its integrity in the context of tissue damage or inflammation remains largely unknown.
Laura Girardet +2 more
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