Results 171 to 178 of about 2,827 (178)

Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation

Biochemical and Biophysical Research Communications, 2008
Arl13b is an atypical Arf/Arl-family GTPase consisting of an extending large C-terminal region (C domain) and Arf-homologous GTP-binding motifs in the N terminus (N domain). Although Arl13b appears to be involved in cilia formation, its precise function and roles of the domains remain unknown.
Yuji, Hori, Tetsuo, Kobayashi, Yorifumi, Kikko, Kenji, Kontani, Toshiaki, Katada   +4 more
openaire   +2 more sources

Novel compound heterozygous variants in ARL13B lead to Joubert syndrome

Journal of Cellular Physiology
AbstractJoubert syndrome (JBTS) is a systematic developmental disorder mainly characterized by a pathognomonic mid‐hindbrain malformation. All known JBTS‐associated genes encode proteins involved in the function of antenna‐like cellular organelle, primary cilium, which plays essential roles in cellular signal transduction and development.
Zaisheng Lin, Yue Shen, Yan Li, Chao Lu, Ying Zhu, Ruida He, Zongfu Cao, Zhe Yin, Huafang Gao, Bin Guo, Xu Ma, Muqing Cao, Minna Luo   +12 more
openaire   +2 more sources

Induction of IMPDH-Based Cytoophidia by a Probable IMP-Dependent ARL13B–IMPDH Interaction

Biochemistry (Moscow)
Inosine Monophosphate Dehydrogenase (IMPDH) catalyzes rate-limiting step of the reaction converting inosine monophosphate (IMP) to guanine nucleotides. IMPDH is up-regulated in the healthy proliferating cells and also in tumor cells to meet their elevated demand for guanine nucleotides. An exclusive regulatory mechanism for this enzyme is filamentation,
Najva Alijani, Razieh Yazdanparast
openaire   +2 more sources

ARL13B Negatively Regulates Kidney Cysts from Within Cilia

Journal of the American Society of Nephrology, 2021
Robert E. Van Sciver, Eduardo Gigante, Tamara Caspary   +2 more
openaire   +1 more source

Ciliary ARL13B Is a Major Driver of Kidney Cystogenesis

Journal of the American Society of Nephrology, 2022
Robert E. Van Sciver, Eduardo Gigante, Tamara Caspary   +2 more
openaire   +1 more source

Arl13b regulates Sonic Hedgehog signaling from outside primary cilia

2019
openaire   +1 more source

Ciliary ARL13B Drives Renal Cystogenesis via Its GEF Activity for ARL3

Journal of the American Society of Nephrology
Robert E. Van Sciver, Avery Forster, Tamara Caspary   +2 more
openaire   +1 more source

Zellbiologische und biochemische Untersuchung von humanem Arl13B

2013
openaire   +1 more source