Results 11 to 20 of about 3,974 (218)

ARL13B controls male reproductive tract physiology through primary and Motile Cilia [PDF]

Communications Biology
ARL13B is a small regulatory GTPase that controls ciliary membrane composition in both motile cilia and non-motile primary cilia. In this study, we investigated the role of ARL13B in the efferent ductules, tubules of the male reproductive tract essential
Céline Augière, Gabriel Campolina-Silva, Aaran Vijayakumaran, Odara Medagedara, Camille Lavoie-Ouellet, Charles Joly Beauparlant, Arnaud Droit, Ferran Barrachina, Kiera Ottino, Maria Agustina Battistone, Kedar Narayan, Rex Hess, Vito Mennella, Clémence Belleannée   +13 more
doaj   +5 more sources

Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols [PDF]

Frontiers in Cell and Developmental Biology
IntroductionCiliopathies are a group of human Mendelian disorders caused by dysfunction of primary cilia, small quasi-ubiquitous sensory organelles. Patients suffering from ciliopathies often display prominent neurodevelopmental phenotypes, underscoring ...
Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu   +18 more
doaj   +4 more sources

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

Molecular Biology of the Cell, 2011
Arl13b, a ciliary protein within the ADP-ribosylation factor family and Ras superfamily of GTPases, is required for ciliary structure but has poorly defined ciliary functions. In this paper, we further characterize the role of Arl13b in cilia by examining mutant cilia in vitro and determining the localization and dynamics of Arl13b within the cilium ...
Richard A Kahn, Tamara Caspary
exaly   +5 more sources

Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Medulloblastoma is the most common malignant pediatric brain tumor. Current therapies are associated with negative side effects, and one-fourth of patients are treatment-resistant or develop tumor progression. Since 30% of medulloblastomas exhibit activation of the Sonic hedgehog (Shh) pathway, much research centers on ...
Sarah N Bay, Alyssa B Long, Tamara Caspary   +2 more
exaly   +5 more sources

Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry [PDF]

Biology Open, 2021
Compositions of proteins and lipids within cilia and on the ciliary membrane are maintained to be distinct from those of the cytoplasm and plasma membrane, respectively, by the presence of the ciliary gate. INPP5E is a phosphoinositide 5-phosphatase that
Hantian Qiu, Sayaka Fujisawa, Shohei Nozaki, Yohei Katoh, Kazuhisa Nakayama   +4 more
doaj   +2 more sources

Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting [PDF]

Genetics, 2021
AbstractPatients with the ciliopathy Joubert syndrome present with physical anomalies, intellectual disability, and a hindbrain malformation described as the “molar tooth sign” due to its appearance on an MRI. This radiological abnormality results from a combination of hypoplasia of the cerebellar vermis and inappropriate targeting of the white matter ...
Sarah K. Suciu, Alyssa B. Long, Tamara Caspary   +2 more
openalex   +6 more sources

Arl13b regulates early endocytic vesicle trafficking [PDF]

Cilia, 2012
We attempted to find new proteins involved in the regulation of the endocytic recycling pathway used by CD1a, a MHC Class I-like lipid antigen-presenting molecule that follows an endocytic recycling pathway similar to that used by MHC Class I and other cargo internalized independently of clathrin.
DC Barral, Salil Garg, Cristina Casalou, Gerald F. Watts, José S. Ramalho, VW Hsu, MB Brenner   +6 more
openalex   +3 more sources

Multiple ciliary localization signals control INPP5E ciliary targeting [PDF]

eLife, 2022
Primary cilia are sensory membrane protrusions whose dysfunction causes ciliopathies. INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert syndrome.
Dario Cilleros-Rodriguez, Raquel Martin-Morales, Pablo Barbeito, Abhijit Deb Roy, Abdelhalim Loukil, Belen Sierra-Rodero, Gonzalo Herranz, Olatz Pampliega, Modesto Redrejo-Rodriguez, Sarah C Goetz, Manuel Izquierdo, Takanari Inoue, Francesc R Garcia-Gonzalo   +12 more
doaj   +7 more sources

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia [PDF]

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +2 more sources

The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b [PDF]

Journal of Cell Science, 2018
ABSTRACT The small GTPase Arl13b is one of the most conserved and ancient ciliary proteins. In human and animals, Arl13b is primarily associated with the ciliary membrane, where it acts as a guanine-nucleotide-exchange factor (GEF) for Arl3 and is implicated in a variety of ciliary and cellular functions.
Yiliu Zhang, Yameng Huang, Amrita Srivathsan, Teck Kwang Lim, Qingsong Lin, Cynthia Y. He   +5 more
openalex   +4 more sources