Ciliary ARL13B prevents obesity in mice.
bioRxiv : the preprint server for biology, 2023 Cilia are near ubiquitous small, cellular appendages critical for cell-to-cell communication. As such, they are involved in diverse developmental and homeostatic processes, including energy homeostasis. ARL13B is a regulatory GTPase highly enriched in cilia.
Terry, Tiffany T. +8 more
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ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane
Biology Open, 2021 INPP5E, a phosphoinositide 5-phosphatase, localizes on the ciliary membrane via its C-terminal prenyl moiety, and maintains the distinct ciliary phosphoinositide composition.
Sayaka Fujisawa +5 more
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ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting [PDF]
Proceedings of the National Academy of Sciences, 2012 Mutations affecting ciliary components cause a series of related genetic disorders in humans, including nephronophthisis (NPHP), Joubert syndrome (JBTS), Meckel-Gruber syndrome (MKS), and Bardet-Biedl syndrome (BBS), which are collectively termed “ciliopathies.” Recent protein–protein interaction studies combined with genetic analyses revealed that ...
Melissa C. Humbert +6 more
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Author response: ARL13B regulates Sonic hedgehog signaling from outside primary cilia
, 2019 Eduardo D. Gigante +4 more
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Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans [PDF]
Journal of Cell Biology, 2010 The small ciliary G protein Arl13b is required for cilium biogenesis and sonic hedgehog signaling and is mutated in patients with Joubert syndrome (JS). In this study, using Caenorhabditis elegans and mammalian cell culture systems, we investigated the poorly understood ciliary and molecular basis of Arl13b function.
Sebiha Cevik +9 more
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ARL3 activation requires the co-GEF BART and effector-mediated turnover
eLife, 2021 The ADP-ribosylation factor-like 3 (ARL3) is a ciliopathy G-protein which regulates the ciliary trafficking of several lipid-modified proteins. ARL3 is activated by its guanine exchange factor (GEF) ARL13B via an unresolved mechanism.
Yasmin ElMaghloob +5 more
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Arl13b regulates early endocytic vesicle trafficking [PDF]
Cilia, 2012 We attempted to find new proteins involved in the regulation of the endocytic recycling pathway used by CD1a, a MHC Class I-like lipid antigen-presenting molecule that follows an endocytic recycling pathway similar to that used by MHC Class I and other cargo internalized independently of clathrin.
Barral, DC +6 more
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Multiple ciliary localization signals control INPP5E ciliary targeting
eLife, 2022 Primary cilia are sensory membrane protrusions whose dysfunction causes ciliopathies. INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert syndrome.
Dario Cilleros-Rodriguez +12 more
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Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development. [PDF]
Dev DynAbstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Spurgin S +8 more
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Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation [PDF]
Nature Neuroscience, 2020 The construction of cerebral cortex begins with the formation of radial glia. Once formed, polarized radial glial cells divide either symmetrically or asymmetrically to balance appropriate production of progenitor cells and neurons. Upon birth, neurons use the processes of radial glia as scaffolding for oriented migration.
Holden Higginbotham +10 more
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