Results 31 to 40 of about 3,974 (218)

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation [PDF]

Nature Neuroscience, 2013
The construction of cerebral cortex begins with the formation of radial glia. Once formed, polarized radial glial cells divide either symmetrically or asymmetrically to balance appropriate production of progenitor cells and neurons. Upon birth, neurons use the processes of radial glia as scaffolding for oriented migration.
Tamara Caspary
exaly   +4 more sources

Alteration of primary cilia and intraflagellar transport 20 (IFT20) expression in oral squamous cell carcinoma (OSCC) cell lines [PDF]

PeerJ
Background Aberrations in primary cilia expression and intraflagellar transport (IFT) protein function have been implicated in tumourigenesis.
Gulam Sakinah-Syed, Jia Shi Liew, Nazia Abdul Majid, Siti Amalina Inche Zainal Abidin   +3 more
doaj   +3 more sources

Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling [PDF]

Cancers, 2019
Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors’ ability to form metastases. Cancer cell migration and invasion are essential for metastasis and rely on the interplay between actin cytoskeleton remodeling and cell adhesion ...
Cristina Casalou, Alexandra Faustino, Fernanda Silva, Inês C. Ferreira, Daniela Vaqueirinho, Andreia Ferreira, Pedro Castanheira, Teresa Barona, José S. Ramalho, Jacinta Serpa, Ana Félix, Duarte C. Barral   +11 more
openalex   +6 more sources

Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation [PDF]

Journal of Biological Chemistry, 2017
Primary cilia are hairlike extensions of the plasma membrane of most mammalian cells that serve specialized signaling functions. To traffic properly to cilia, multiple cilia proteins rely on palmitoylation, the post-translational attachment of a saturated 16-carbon lipid.
Kasturi Roy, Stephanie Jerman, Levente József, Thomas McNamara, Ginikanwa Onyekaba, Zhaoxia Sun, Ethan P. Marin   +6 more
openalex   +4 more sources

Arl13b regulates Shh signaling from both inside and outside the cilium

Molecular Biology of the Cell, 2016
The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling. Missense mutations in ARL13B can cause the ciliopathy Joubert syndrome (JS), and the mouse null allele is embryonic lethal. We used mouse embryonic fibroblasts as a system to determine the effects of Arl13b mutations on Shh signaling.
Sarah K Suciu, Richard A Kahn, Tamara Caspary   +2 more
exaly   +4 more sources

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria [PDF]

Journal of Cellular Physiology, 2017
This work was supported by the Medical Research Council (MR/L002876/1), the Royal College of Surgeons of England, Fondazione Telethon Italy (GGP10058), and Associazione Italiana Malati di Alcaptonuria (AimAKU ...
Bernardini, Braconi, Braconi, Braconi, Brown, Buttitta, Capin-Gutierrez, Caspary, Clement, Corbit, Cruz, Dai, Engel, Gallagher, Geminiani, Goldring, Goldring, Haudenschild, He, Helliwell, Hernandez-Hernandez, Hogan, Holloway, Huangfu, Huangfu, Khayyeri, Kim, La Du, Larkins, Li, Li, Lin, Lu, Ludington, Mahjoub, Mannoni, Mariani, McGlashan, McMurray, Millucci, Mistry, Moran, Mow, Nager, Neely, Neely, Ohashi, Perez, Pitaval, Polizio, Praetorius, Qin, Reilova-Velez, Renault, Rohatgi, Ross, Ruiz-Heiland, Sasaki, Satir, Schneider, Shuang, Silverman, Tanuma, Thompson, Thompson, Thyberg, Tinti, Tran, Tucker, Tummala, Valderrama, Wang, Wann, Waters, Wei, Wen, Wong, Wood, Wright, Zhu   +79 more
core   +7 more sources

Arl13b in Primary Cilia Regulates the Migration and Placement of Interneurons in the Developing Cerebral Cortex [PDF]

Developmental Cell, 2012
Coordinated migration and placement of interneurons and projection neurons lead to functional connectivity in the cerebral cortex; defective neuronal migration and the resultant connectivity changes underlie the cognitive defects in a spectrum of neurological disorders.
Tamara Caspary, Ricardo Ferreira, Jan John   +2 more
exaly   +4 more sources

Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity [PDF]

European Journal of Human Genetics, 2014
Joubert syndrome (JS) is a genetically heterogeneous autosomal recessive ciliopathy with 22 genes implicated to date, including a small, ciliary GTPase, ARL13B. ARL13B is required for cilia formation in vertebrates. JS patients display multiple symptoms characterized by ataxia due to the cerebellar vermis hypoplasia, and that can also include ocular ...
Sophie Thomas, Vincent Cantagrel, Laura Mariani, Valérie Serre, Jieun Lee, Nadia Elkhartoufi, Pascale de Lonlay, Isabelle Desguerre, Arnold Münnich, Nathalie Boddaert, Stanislas Lyonnet, Michel Vekemans, Steven Lisgo, Tamara Caspary, Joseph G. Gleeson, Tania Attié‐Bitach   +15 more
openalex   +6 more sources

Ciliary genes arl13b, ahi1 and cc2d2a differentially modify expression of visual acuity phenotypes but do not enhance retinal degeneration due to mutation of cep290 in zebrafish.

PLoS ONE, 2019
Mutations in the gene Centrosomal Protein 290 kDa (CEP290) result in multiple ciliopathies ranging from the neonatal lethal disorder Meckel-Gruber Syndrome to multi-systemic disorders such as Joubert Syndrome and Bardet-Biedl Syndrome to nonsyndromic ...
Emma M Lessieur, Ping Song, Gabrielle C Nivar, Ellen M Piccillo, Joseph Fogerty, Richard Rozic, Brian D Perkins   +6 more
doaj   +3 more sources

Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway [PDF]

Cancer Research, 2017
Abstract Inhibitors of the Hedgehog (Hh) pathway transducer Smoothened (Smo) have been approved for cancer treatment, but Smo mutations often lead to tumor resistance and it remains unclear how Smo is regulated. In this study, we identified the small GTPase Arl13b as a novel partner and regulator of Smo.
Linlin Xu, Limin Chen, Quqin Lu
exaly   +4 more sources