Results 91 to 100 of about 2,018,863 (346)
Chairman's report / East Arm Hospital Management Board.
Aided by the experiences of the 1980-1981 period, the East Arm Hospital Management Board looked forward to its role for the next period. Between July 1981 to 31 March 1982 the Board made a significant contribution for the overall good of the hospital and
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Background/Objectives: To address the inconsistent provision of specialist physical education (PE) in primary schools, this study investigated the comparative efficacy of distinct team teaching configurations.
Gabriela Luptáková +6 more
doaj +1 more source
A modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation method coupled with liquid chromatography–tandem mass spectrometry (LC–MS/MS) was proposed for the determination of α-, β-, and γ-hexabromocyclododecane (HBCD ...
Linda Okšová, Peter Tölgyessy
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Failed Latarjet surgery: why, how, and what next?
Background: The Latarjet procedure is an established and popular procedure for recurrent anterior shoulder instability; however, to our knowledge, few studies have reported on the outcomes of revision for failed Latarjet surgery.
Umair Khan, MBChB, MRes(Dist) +3 more
doaj +1 more source
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
The arm of a large-scale bronze statue from Aigion, Achaea, Greece
The arm of the large-scale bronze statue presented in the current research was handed over in 1951 to the Ephorate of Antiquities in Aigio of Achaia and constitutes a typical yet exquisite example of Peloponnesian oversized statuary in bronze.
Andreas G. Vordos
doaj +1 more source

