Results 81 to 90 of about 2,018,863 (346)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Rapid scale-up of hospital-at-home services during wartime: lessons learned from the Sheba Medical Center experience

Frontiers in Medicine
BackgroundSheba BEYOND, the telemedicine-governed hospital within the Sheba medical center includes a unique telemedicine-based service for internal-medicine patients suffering from acute illness since 2020, serving as a viable alternative to in-hospital
Anat Ekka Zohar, Anat Ekka Zohar, Boris Fizdel, Liat Aroshass, Liron Vaserman, Galia Barkai, Galia Barkai, Shani Edelman, Rachel Sarafraz, Eyal Leshem, Eyal Leshem, Matan Peri, Matan Peri, Asaf Biber, Asaf Biber, Yael Frenkel Nir, Yael Frenkel Nir, Gad Segal, Gad Segal   +18 more
doaj   +1 more source

ARM-Seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

Nature Methods, 2015
High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles of small RNAs, but RNAs containing modified nucleosides may escape detection when those modifications interfere with reverse transcription during RNA-seq library ...
A. E. Cozen, Erin Quartley, A. Holmes, Eva H. Robinson, E. Phizicky, T. Lowe   +5 more
semanticscholar   +1 more source

On the cost functions for the control of the human arm movement [PDF]

, 1990
Cruse H, Wischmeyer E, Brüwer M, Brockfeld P, Drees A. On the cost functions for the control of the human arm movement. Biological cybernetics.
Wischmeyer, E., Brüwer, M., Brockfeld, P., Drees, A., Cruse, Holk   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

تأثیر حذف نوسان اندام فوقانی بر جابه‌جایی سه بعدی مرکز جرم بدن در حین راه رفتن

مجله دانشکده پزشکی اصفهان, 2019
Background: Since the effect of immobilization of the upper limb, despite its importance, is usually neglected in the analysis of gait, the purpose of the present study was to assess the effect of removal upper limb arm swing on 3-dimentional (3D) body ...
Razieh Yousefian-Molla, Heydar Sadeghi, Farzam Farahmand, Mohammad Ali Azarbayjani   +3 more
doaj   +1 more source

Arm Swing as a Potential New Prodromal Marker of Parkinson’s Disease

Movement Disorders, 2016
Reduced arm swing is a well‐known clinical feature of Parkinson's disease (PD), often observed early in the course of the disease. We hypothesized that subtle changes in arm swing and axial rotation may also be detectable in the prodromal phase.
A. Mirelman, H. Bernad-Elazari, Avner Thaler, Eytan Giladi-Yacobi, T. Gurevich, M. Gana-Weisz, R. Saunders-Pullman, D. Raymond, N. Doan, S. Bressman, K. Marder, R. Alcalay, A. Rao, D. Berg, K. Brockmann, J. Aasly, B. Warø, E. Tolosa, D. Vilas, C. Pont-Sunyer, A. Orr-Urtreger, J. Hausdorff, Nir Giladi   +22 more
semanticscholar   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

ARM’s Perspective on the First Joint Clinical Assessments for ATMPs: Challenges and Opportunities on the Path Ahead

Journal of Market Access & Health Policy
Advanced Therapy Medicinal Products (ATMPs) are revolutionising modern medicine. By addressing the root cause rather than the symptoms of disease, ATMPs hold the promise of long-lasting benefits or even cures for severe, genetic, and rare diseases ...
Paolo Morgese, Stephen Majors, Dilip Patel   +2 more
doaj   +1 more source