Results 41 to 50 of about 122,317 (249)

Reaching towards a bionic arm

The FASEB Journal, 2006
Reaching towards a bionic arm The biggest challenge for a bionic arm is to communicate effectively with its user. My laboratory has developed new communication tools that allow prospective users of a bionic arm to regain proportional control over several movements of the hand, thus restoring a degree of dexterity.
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

LINKING MOTOR-RELATED BRAIN POTENTIALS AND VELOCITY PROFILES IN MULTI-JOINT ARM REACHING MOVEMENTS

Frontiers in Human Neuroscience, 2014
The study of the movement related brain potentials (MRPBs) needs accurate technical approaches to disentangle the specific patterns of bran activity during the preparation and execution of movements.
Julià L Amengual, Josep eMarco-Pallares, Josep eMarco-Pallares, Carles eGrau, Thomas F Münte, Antoni eRodriguez-Fornells, Antoni eRodriguez-Fornells, Antoni eRodriguez-Fornells   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Impact of motor task conditions on end-point kinematics and trunk movements during goal-directed arm reach

Scientific Reports
Task conditions significantly impact human motor control. We investigated how task type, difficulty, and constraints influence the kinematics of goal-directed arm reaching. Non-disabled young adults performed two distinct goal-directed arm reaching tasks:
Bokkyu Kim, Jaimie Girnis, Vanessa Sweet, Tobias Nobiling, Tarek Agag, Christopher Neville   +5 more
doaj   +1 more source

An EEG study on the somatotopic organisation of sensorimotor cortex activation during action execution and observation in infancy

Developmental Cognitive Neuroscience, 2015
Previous studies have shown that sensorimotor cortex activation is somatotopically-organised during action execution and observation in adulthood. Here we aimed to investigate the development of this phenomenon in infancy. We elicited arm and leg actions
Carina C.J.M. de Klerk, Mark H. Johnson, Victoria Southgate   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Effects of Rhythmic Auditory Stimulation During Hemiplegic Arm Reaching in Individuals with Stroke: An Exploratory Study

Hong Kong Journal of Occupational Therapy, 2014
Objective/Background: This study investigated the effects of rhythmic auditory stimulation (RAS) on muscle activity and elbow motion during arm reaching with hemiplegic arm in participants with stroke. Methods: Sixteen adults with stroke who resided in a
Jung-ran Kim, Min-ye Jung, Eun-young Yoo, Ji-Hyuk Park, Sung-Hoon Kim, Jin Lee   +5 more
doaj   +1 more source