Results 61 to 70 of about 570,610 (284)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Learning Grasps in a Synergy-based Framework [PDF]

, 2017
In this work, a supervised learning strategy has been applied in conjunction with a control strategy to provide anthropomorphic hand-arm systems with autonomous grasping capabilities.
Ficuciello, Fanny, Siciliano, Bruno, Zaccara, Damiano   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Computational Approach for Human-like Motion Generation in Upper Limb Exoskeletons Supporting Scapulohumeral Rhythms

, 2017
This paper proposes a computational approach for generation of reference path for upper-limb exoskeletons considering the scapulohumeral rhythms of the shoulder.
Langari, Reza, Soltani-Zarrin, Rana, Tafreshi, Reza, Zeiaee, Amin   +3 more
core   +1 more source

Integration of visual and joint information to enable linear reaching motions [PDF]

, 2017
A new dynamics-driven control law was developed for a robot arm, based on the feedback control law which uses the linear transformation directly from work space to joint space.
AG Feldman, DM Wolpert, DM Wolpert, DM Wolpert, J Nakanishi, JA Nelder, JR Flanagan, K Hashimoto, M Desmurget, M Kawato, MJ Giummarra, NP Holmes, P Morasso, PI Corke, S Macfarlane, T Mitsuda, WJ Wilson   +16 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An EEG study on the somatotopic organisation of sensorimotor cortex activation during action execution and observation in infancy

Developmental Cognitive Neuroscience, 2015
Previous studies have shown that sensorimotor cortex activation is somatotopically-organised during action execution and observation in adulthood. Here we aimed to investigate the development of this phenomenon in infancy. We elicited arm and leg actions
Carina C.J.M. de Klerk, Mark H. Johnson, Victoria Southgate   +2 more
doaj   +1 more source

Between Limb Muscle Co-activation Patterns in the Paretic Arm During Non-paretic Arm Tasks in Hemiparetic Cerebral Palsy

Frontiers in Neuroscience, 2021
Tasks of daily life require the independent use of the arms and hands. Individuals with hemiparetic cerebral palsy (HCP) often experience difficulty with fine motor tasks demonstrating mirrored movements between the arms.
Nayo M. Hill, Nayo M. Hill, Theresa Sukal-Moulton, Theresa Sukal-Moulton, Julius P. A. Dewald, Julius P. A. Dewald, Julius P. A. Dewald   +6 more
doaj   +1 more source

Sensitivity to Hand Path Curvature during Reaching [PDF]

, 2003
People optimize reaching to make straight and smooth movements. We performed experiments characterizing human sensitivity to hand path deviations from a straight reach. Vision of the arm was blocked.
Lillis, Kyle P., Scheidt, Robert A.
core   +1 more source

Improving Brain–Machine Interface Performance by Decoding Intended Future Movements [PDF]

, 2013
Objective. A brain–machine interface (BMI) records neural signals in real time from a subject\u27s brain, interprets them as motor commands, and reroutes them to a device such as a robotic arm, so as to restore lost motor function.
Fagg, Andrew H., Hatsopoulos, Nicholas G., Suminski, Aaron J., Willett, Francis R.   +3 more
core   +2 more sources