Results 51 to 60 of about 120,360 (287)
Forward Inverse Relaxation Model Incorporating Movement Duration Optimization
Brain Sciences, 2021 A computational trajectory formation model based on the optimization principle, which introduces the forward inverse relaxation model (FIRM) as the hardware and algorithm, represents the features of human arm movements well.
Misaki Takeda, Isao Nambu, Yasuhiro Wada
doaj +1 more source
Body posture modulates imagined arm movements and responds to them
, 2013 Imagined movements are thought to simulate physical ones, with similar behavioral constraints and neurophysiological activation patterns, and an inhibition mechanism that suppresses movement execution.
Boulton, H +3 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Early life experience sets hard limits on motor learning as evidenced from artificial arm use
eLife, 2021 The study of artificial arms provides a unique opportunity to address long-standing questions on sensorimotor plasticity and development. Learning to use an artificial arm arguably depends on fundamental building blocks of body representation and would ...
Roni O Maimon-Mor +4 more
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Kinematically Optimal Catching a Flying Ball with a Hand-Arm-System
, 2010 A robotic ball-catching system built from a multi- purpose 7-DOF lightweight arm (DLR-LWR-III) and a 12 DOF four-fingered hand (DLR-Hand-II) is presented.
Hirzinger, Gerd +5 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Journal of NeuroEngineering and Rehabilitation, 2006 Background and purpose Providing active assistance to complete desired arm movements is a common technique in upper extremity rehabilitation after stroke.
Rymer W Zev +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source