Results 51 to 60 of about 1,061,568 (282)

Early life experience sets hard limits on motor learning as evidenced from artificial arm use

eLife, 2021
The study of artificial arms provides a unique opportunity to address long-standing questions on sensorimotor plasticity and development. Learning to use an artificial arm arguably depends on fundamental building blocks of body representation and would ...
Roni O Maimon-Mor, Hunter R Schone, David Henderson Slater, A Aldo Faisal, Tamar R Makin   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Robot-assisted reaching exercise promotes arm movement recovery in chronic hemiparetic stroke: a randomized controlled pilot study

Journal of NeuroEngineering and Rehabilitation, 2006
Background and purpose Providing active assistance to complete desired arm movements is a common technique in upper extremity rehabilitation after stroke.
Rymer W Zev, Zygman Michele L, Kahn Leonard E, Reinkensmeyer David J   +3 more
doaj   +1 more source

Reaching towards a bionic arm

The FASEB Journal, 2006
Reaching towards a bionic arm The biggest challenge for a bionic arm is to communicate effectively with its user. My laboratory has developed new communication tools that allow prospective users of a bionic arm to regain proportional control over several movements of the hand, thus restoring a degree of dexterity.
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

LINKING MOTOR-RELATED BRAIN POTENTIALS AND VELOCITY PROFILES IN MULTI-JOINT ARM REACHING MOVEMENTS

Frontiers in Human Neuroscience, 2014
The study of the movement related brain potentials (MRPBs) needs accurate technical approaches to disentangle the specific patterns of bran activity during the preparation and execution of movements.
Julià L Amengual, Josep eMarco-Pallares, Josep eMarco-Pallares, Carles eGrau, Thomas F Münte, Antoni eRodriguez-Fornells, Antoni eRodriguez-Fornells, Antoni eRodriguez-Fornells   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact of motor task conditions on end-point kinematics and trunk movements during goal-directed arm reach

Scientific Reports
Task conditions significantly impact human motor control. We investigated how task type, difficulty, and constraints influence the kinematics of goal-directed arm reaching. Non-disabled young adults performed two distinct goal-directed arm reaching tasks:
Bokkyu Kim, Jaimie Girnis, Vanessa Sweet, Tobias Nobiling, Tarek Agag, Christopher Neville   +5 more
doaj   +1 more source