Results 71 to 80 of about 570,610 (284)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Impact of motor task conditions on end-point kinematics and trunk movements during goal-directed arm reach

Scientific Reports
Task conditions significantly impact human motor control. We investigated how task type, difficulty, and constraints influence the kinematics of goal-directed arm reaching. Non-disabled young adults performed two distinct goal-directed arm reaching tasks:
Bokkyu Kim, Jaimie Girnis, Vanessa Sweet, Tobias Nobiling, Tarek Agag, Christopher Neville   +5 more
doaj   +1 more source

Effects of Rhythmic Auditory Stimulation During Hemiplegic Arm Reaching in Individuals with Stroke: An Exploratory Study

Hong Kong Journal of Occupational Therapy, 2014
Objective/Background: This study investigated the effects of rhythmic auditory stimulation (RAS) on muscle activity and elbow motion during arm reaching with hemiplegic arm in participants with stroke. Methods: Sixteen adults with stroke who resided in a
Jung-ran Kim, Min-ye Jung, Eun-young Yoo, Ji-Hyuk Park, Sung-Hoon Kim, Jin Lee   +5 more
doaj   +1 more source

Double-Step Paradigm in Microgravity: Preservation of Sensorimotor Flexibility in Altered Gravitational Force Field

Frontiers in Physiology, 2020
The way we can correct our ongoing movements to sudden and unforeseen perturbations is key to our ability to rapidly adjust our behavior to novel environmental demands.
L. Bringoux, T. Macaluso, P. Sainton, L. Chomienne, F. Buloup, L. Mouchnino, M. Simoneau, M. Simoneau, J. Blouin   +8 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Spiral Structure of the Milky Way, Cosmic Rays, and Ice Age Epochs on Earth [PDF]

, 2002
The short term variability of the Galactic cosmic ray flux (CRF) reaching Earth has been previously associated with variations in the global low altitude cloud cover. This CRF variability arises from changes in the solar wind strength.
Alvarez, Amaral, Avedisova, Barry, Bazilevskaya, Beer, Begelman, Bell, Berezinskiı̆, Binney, Blitz, Christensen-Dalsgaard, Comeron, Compton, Creze, Dame, Dickinson, Dilke, Dopita, Dragicevich, Efremov, Egorova, Elmegreen, Feitzinger, Fernández, Frakes, Friis-Christensen, Gallagher, Gardiner, Georgelin, Gordon, Grivnev, Grivnev, Guyodo, Haigh, Hambrey, Hampel, Harrison, Hernandez, Heyer, Hodell, Hoffman, Hoyle, Hoyle, Huber, Ivanov, Kirkby, Labitzke, Lavielle, Leitch, Lin, Lisenfeld, Lo, Loktin, Longair, Lukasiak, Lynds, Marsh, Michel, Mishurov, Mishurov, Napier, Neff, Nelson, Ney, Nir J. Shaviv, Olling, Palle Bago, Palous, Perko, Pudovkin, Rind, Robin, Rocha-Pinto, Rocha-Pinto, Ruphy, Schaeffer, Shaviv, Simpson, Singer, Soon, Soon, Steiner, Stozhkov, Svensmark, Svensmark, Tammann, Taylor, Tinsley, Vallenari, Vallée, Vallée, van den Bergh, Veizer, Voshage, Voshage, Voshage, Webber, Westerlund, Wiedenbeck, Wielen, Wielen, Williams, Yabushita, Yuan, Yuan, Zachos   +106 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Accuracy deficits during robotic time-constrained reaching are related to altered prefrontal cortex activity in children with cerebral palsy

Journal of NeuroEngineering and Rehabilitation
Background The prefrontal cortex (PFC) is an important node for action planning in the frontoparietal reaching network but its role in reaching in children with cerebral palsy (CP) is unexplored.
Owais A. Khan, Tarkeshwar Singh, Deborah A. Barany, Christopher M. Modlesky   +3 more
doaj   +1 more source

West Virginia: Round 1 - State Level Field Network Study of the Implementation of the Affordable Care Act [PDF]

, 2014
This report is part of a series of 21 state and regional studies examining the rollout of the ACA. The national network -- with 36 states and 61 researchers -- is led by the Rockefeller Institute of Government, the public policy research arm of the State
Christopher Plein
core  

Catching Spiral - S0 transition in groups. Insights from SPH simulations with chemo-photometric implementation

, 2013
We are investigating the co-evolution of galaxies within groups combining multi-wavelength photometric and 2D kinematical observations. Here we focus on S0s showing star formation in ring/arm-like structures.
Bettoni, D., Galletta, G., Marino, A., Mazzei, P., Rampazzo, R.   +4 more
core   +1 more source