Results 71 to 80 of about 2,382,973 (247)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Vastuolulised sõjad ja kestev kolonisatsioon neenetsi tundras

open access: yesKeel ja Kirjandus
Contested wars and ongoing colonization in the Nenets tundra This article examines how long-term colonial domination shapes attitudes toward war, violence, and the state among Nenets reindeer herders in the European tundra and the Polar Urals. Drawing
Laur Vallikivi
doaj   +1 more source

A role played by the All-Union Communist Party (Bolsheviks) Central Committee Bureau for Lithuania in suppressing resistance of partisans (November 1944–March 1947)

open access: yesGenocidas ir Rezistencija, 2018
By a decision of the Organisational Bureau of the All-Union Communist Party (Bolsheviks) Central Committee, Mikhail Suslov was dismissed as chairman of the ACP(B) CC Bureau for Lithuanian Affairs and appointed a member of the Organisational Bureau ...
Mindaugas Pocius
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Lithuanian partisans from political philosophy perspective

open access: yesGenocidas ir Rezistencija, 2006
Is partisan struggle legal? What is the difference between partisans and terrorists? Where are the limits of the legitimacy of partisan activity and how should the Lithuanian partisans be evaluated from this point of view?
Mantas Adomėnas
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Partisans about memory and soviet heritage

open access: yesGenocidas ir Rezistencija, 2000
On 30 March 1949 the headquarters of the Lithuanian partisan Duke Margis’ Detachment (Algimantas District) issued an appeal “Lithuanians, let’s collect the material of the Bolshevik rule” and instructions on how to collect this material.
Arvydas Anušauskas
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

Cognitive task analysis: current use and practice in the UK Armed Forces and elsewhere

open access: yes, 2005
This report is concerned with Cognitive Task Analysis (CTA). It covers the origins, growth, and diversity of CTA as an activity, current practice in the UK Armed Forces and civilian operations, reviews an extensive range of archive material and draws a ...
McMaster, Richard   +5 more
core   +1 more source

Special MVD-MGB Troops in Lithuania (1945–1959)

open access: yesGenocidas ir Rezistencija, 1997
In 1950, V. Abakumov, Minister of State Security of the USSR, ordered the leadership of the LSSR MGB to: “use all means to solve the main task – to penetrate, through the agency, the centres, headquarters and other leadership units of bandits and ...
Mindaugas Pocius
doaj   +1 more source

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