Results 61 to 70 of about 29,080 (334)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Genocidas ir Rezistencija, 2011 The post-war guerrilla warfare in Lithuania was nothing new since the traditions of the guerrilla movement dated back to the 1919–1923 battles for independence and confrontations with Polish forces in the neutral territory.
Vytautas Jokubauskas
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Some Features of the Lithuanian Resistance Phenomenon
Genocidas ir Rezistencija, 2003 Speaking presently about the post-war resistance, it is already possible to refer to authentic documentation, which allows analysis of the political and ideological features of the resistance.
Arvydas Anušauskas
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
NKVD kariuomenės dokumentai Rusijos karo archyve
Genocidas ir Rezistencija, 1997 Historians studying the armed struggle against the Soviet invaders in 1944–1953 are constantly confronted with the problem of identifying the military structures of occupation.
Arvydas Anušauskas
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2020 Since 2017, English-speaking regions of Cameroon have witnessed armed conflict in its towns and villages with far-reaching repercussions. This is perhaps one of the worst endogenous armed conflicts in Cameroon since independence in 1960 and reunification
Confidence Chia Ngam +1 more
semanticscholar +1 more source
The Activities of NKVD Forces of Rear Defence Fronts in Lithuania (1944–1945)
Genocidas ir Rezistencija, 1997 This is an article on the NKVD army of the 3rd Belarusian background front and is a fragment of a paper on those Soviet military occupying forces (rifle regiments, border regiments and detachments, destruction battalions made up of collaborators) that ...
Juozas Starkauskas
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source