Results 41 to 50 of about 40,518 (302)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Gestalt Theory, 2020 Several subdisciplines within historiography, most notably the arms and armour or martial arts studies, are interested in inferring physical qualities of historical material objects from historical sources.
Talaga Maciej, Ridgeway Harrison
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The paradoxical marketing of sports equipment brands. [El marketing paradójico de las marcas de material deportivo]. [PDF]
Revista Internacional de Ciencias del Deporte, 2014 As Ko (2013) pointed out, the sport industry is a large and fast growing business. The U.S. market accounted for as much as $400-435 billion in 2012.
José A. Martínez
doaj +1 more source
Fifth Canadian Armoured Division: Introduction to Battle [PDF]
, 2012 The Canadian government authorized the formation of 1st Canadian Armoured Division (CAD) early in 1941. It organized at Camp Borden in March and, redesignated 5th CAD, sailed for the United Kingdom in the fall.
McAndrew, William
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Carolingian influences on the West Slavs' arms and armour
Fasciculi Archaeologiae Historicae, 1994 ...
Krzysztof Wachowski
doaj
Weaponry from the Vassals House in Křivoklát from the 15th Century
Fasciculi Archaeologiae Historicae, 2020 This paper aims at discussing an exceptionally well dated assemblage of pre-Hussite weaponry in Bohemia which survived in Křivoklát Castle. This castle was one of the most important medieval defensive seats of the kings of Bohemia.
Josef Hložek, Olgierd Ławrynowicz
doaj +1 more source