Results 51 to 60 of about 2,374 (261)
Weaponry from the Vassals House in Křivoklát from the 15th Century
Fasciculi Archaeologiae Historicae, 2020 This paper aims at discussing an exceptionally well dated assemblage of pre-Hussite weaponry in Bohemia which survived in Křivoklát Castle. This castle was one of the most important medieval defensive seats of the kings of Bohemia.
Josef Hložek, Olgierd Ławrynowicz
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Acta Periodica Duellatorum, 2019 The sixteenth-century Collectanea of the condottiero Pietro Monte contains some of the most thorough writings that exist pertaining to the use of staff weapons.
Deacon Jacob Henry +1 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Fasciculi Archaeologiae Historicae, 2014 During the reign of Mithradates VI Eupator, king of Pontus, the Cimmerian Bosporus was incorporated to the kingdom of Pontus. Detachments of the Mithradatic army were located on the Bosporus.
Mariusz Mielczarek
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Fasciculi Archaeologiae Historicae, 2020 This paper discusses problems of changes in military equipment that was in use in the historical Sanok Land. Being situated in the borderland of Piast Poland and the Halych-Volhynia Principality, Sanok was located at the interface of two civilisations –
Piotr N. Kotowicz, Paweł Skowroński
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Burial of a Man-At-Arms in Kudash I Burial Ground
Поволжская археология, 2017 The article features a comprehensive analysis of items discovered in male burial 160 of Kudash I burial ground – a unique source of materials for the research of interactions between the local and foreign population on the Middle Kama region in 3rd – 5th
Kazantseva Olga A. , Nagiev Zaur Sh.
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