Results 51 to 60 of about 1,843 (294)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Carolingian influences on the West Slavs' arms and armour
Fasciculi Archaeologiae Historicae, 1994 ...
Krzysztof Wachowski
doaj
Weaponry from the Vassals House in Křivoklát from the 15th Century
Fasciculi Archaeologiae Historicae, 2020 This paper aims at discussing an exceptionally well dated assemblage of pre-Hussite weaponry in Bohemia which survived in Křivoklát Castle. This castle was one of the most important medieval defensive seats of the kings of Bohemia.
Josef Hložek, Olgierd Ławrynowicz
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Acta Periodica Duellatorum, 2019 The sixteenth-century Collectanea of the condottiero Pietro Monte contains some of the most thorough writings that exist pertaining to the use of staff weapons.
Deacon Jacob Henry +1 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Representations of Antique Arms and Armour in the Architectural decor of St. Petersburg [PDF]
, 2017 The matter of the article is the representation of ancient arms and armour in Saint Petetrburg’s architecture. Classisism style (1770-1840) and New Classicism style (1905-1915) are studied.
NIKONENKO, Sergey
core +2 more sources
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Fasciculi Archaeologiae Historicae, 2014 During the reign of Mithradates VI Eupator, king of Pontus, the Cimmerian Bosporus was incorporated to the kingdom of Pontus. Detachments of the Mithradatic army were located on the Bosporus.
Mariusz Mielczarek
doaj
Fasciculi Archaeologiae Historicae, 2020 This paper discusses problems of changes in military equipment that was in use in the historical Sanok Land. Being situated in the borderland of Piast Poland and the Halych-Volhynia Principality, Sanok was located at the interface of two civilisations –
Piotr N. Kotowicz, Paweł Skowroński
doaj +1 more source