Results 51 to 60 of about 1,506 (289)
The paradoxical marketing of sports equipment brands. [El marketing paradójico de las marcas de material deportivo]. [PDF]
Revista Internacional de Ciencias del Deporte, 2014 As Ko (2013) pointed out, the sport industry is a large and fast growing business. The U.S. market accounted for as much as $400-435 billion in 2012.
José A. Martínez
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Weaponry from the Vassals House in Křivoklát from the 15th Century
Fasciculi Archaeologiae Historicae, 2020 This paper aims at discussing an exceptionally well dated assemblage of pre-Hussite weaponry in Bohemia which survived in Křivoklát Castle. This castle was one of the most important medieval defensive seats of the kings of Bohemia.
Josef Hložek, Olgierd Ławrynowicz
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
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Acta Periodica Duellatorum, 2019 The sixteenth-century Collectanea of the condottiero Pietro Monte contains some of the most thorough writings that exist pertaining to the use of staff weapons.
Deacon Jacob Henry +1 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
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Fasciculi Archaeologiae Historicae, 2020 This paper discusses problems of changes in military equipment that was in use in the historical Sanok Land. Being situated in the borderland of Piast Poland and the Halych-Volhynia Principality, Sanok was located at the interface of two civilisations –
Piotr N. Kotowicz, Paweł Skowroński
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Fasciculi Archaeologiae Historicae, 2014 During the reign of Mithradates VI Eupator, king of Pontus, the Cimmerian Bosporus was incorporated to the kingdom of Pontus. Detachments of the Mithradatic army were located on the Bosporus.
Mariusz Mielczarek
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