Results 31 to 40 of about 357,058 (252)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Journal for Peace and Nuclear Disarmament, 2019 On the way to a new world order we do not yet know, disorder is the new normal. The world is in a state of flux. Six features are particularly noteworthy. (1) Sovereign states are reemphasized and reconfirmed as the basic building blocks of international
Sverre Lodgaard
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Taking Forward the Dialogue on Nuclear Risk Reduction
Journal for Peace and Nuclear Disarmament, 2021 Building on the existing political momentum, this article seeks to deepen the international discussion on nuclear risk reduction through track 1.5 and track 2.0 dialogues.
Petr Topychkanov
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
NUST Journal of International Peace and StabilityCivil-military relations constitute a complex area of international relations through the interaction of military institutions, civil society, and other governmental bureaucracies.
Sardar Jehanzaib Ghalib
doaj +1 more source
Journal for Peace and Nuclear Disarmament, 2021 The United States and Russia agreed to extend the 2010 New START Treaty in February 2021. Many analysts believed that this step would reinvigorate the US-Russian arms control process, lead to deeper reductions in nuclear weapons, and possibly pave the ...
Amy F. Woolf
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Arms Control Dialogue is Japan’s Interest: An Agenda for a New Nuclear Posture Review
Journal for Peace and Nuclear Disarmament, 2021 In debates on the Biden administration’s Nuclear Posture Review (NPR), the issue that has attracted the most attention in Japan is whether or not the declaratory policy of “no first use” or “sole purpose” of nuclear weapons will be adopted.
Nobumasa Akiyama
doaj +1 more source