Results 41 to 50 of about 16,296,718 (378)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Taking Forward the Dialogue on Nuclear Risk Reduction

Journal for Peace and Nuclear Disarmament, 2021
Building on the existing political momentum, this article seeks to deepen the international discussion on nuclear risk reduction through track 1.5 and track 2.0 dialogues.
Petr Topychkanov
doaj   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Irreversibility in Nuclear Arms Control: Lessons from the US-Soviet/Russian Arms Control Process

Journal for Peace and Nuclear Disarmament
The United States and Soviet Union/Russian Federation signed several arms control treaties that mandated reductions in their numbers of deployed nuclear weapons.
Amy F. Woolf
doaj   +1 more source

Changes in International Arms Control and China’s Role

China Quarterly of International Strategic Studies, 2020
The international arms control regime has arrived at a crossroads as the United States pulls out of a number of international treaties and launches a new round of defense and military buildup in pursuit of absolute strategic and technological superiority.
Chunsi Wu
doaj   +1 more source

Arms Control and Delivery Vehicles: Challenges and Ways Forward

Journal for Peace and Nuclear Disarmament, 2022
Nuclear arms control remains a priority for the foreseeable future for many stakeholders, and proposals have emerged to focus on capping nuclear warheads of the main nuclear-weapon states.
Emmanuelle Maitre
doaj   +1 more source

Keys to unblocking multilateral nuclear arms control [PDF]

, 2002
Includes bibliographical references (p. 9.) "July 2002"This article outlines the activities that must be undertaken and the issues that must be addressed in order for multilateral arms control to succeed in the 21st century, given the current US ...
Sands, Amy, Singer, Clifford E.
core  

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Real‐world evidence to support regulatory decision‐making for medicines: Considerations for external control arms

Pharmacoepidemiology and Drug Safety, 2020
Randomized clinical trials (RCTs) are the gold standard in producing clinical evidence of efficacy and safety of medical interventions. More recently, a new paradigm is emerging—specifically within the context of preauthorization regulatory decision ...
M. Burcu, N. Dreyer, J. Franklin, Michael D. Blum, C. Critchlow, E. Perfetto, Wei Zhou   +6 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source