Results 41 to 50 of about 357,058 (252)
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Complex & Intelligent SystemsAccurate traffic flow forecasting serves as a cornerstone for intelligent transportation systems, enabling proactive accident prevention and metropolitan mobility optimization.
Wei Li +6 more
doaj +1 more source
Italy and Arms Control: Identity Dilemmas [PDF]
Современная ЕвропаThe article analyses the evolution of Italy's foreign policy on the most important multilateral treaties in the field of arms control, their proliferation and disarmament.
Nadezhda Arbatova
doaj +1 more source
Fault Lines between East and West: Which Levers Can Rebuild Confidence?
Journal for Peace and Nuclear Disarmament, 2020 Several regional fault lines will define the character of relations between East and West in the coming years. It is already evident that notably in the Baltic region, both NATO and Russia have squandered a great deal of confidence, which will have to be
Nadja Douglas
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Behavioral Arms Control and East Asia
Journal for Peace and Nuclear DisarmamentGrowing political and military tensions between China and the United States make it necessary to think of novel arms control approaches on nuclear weapons and certain emerging technologies, designed to include China and other actors.
Ulrich Kühn, Heather Williams
doaj +1 more source
Международная аналитика, 2016 The article is devoted to some critical aspects of correspondence of the Alliance status to the basic norms of international law. It also centers on specific actual steps of the realization of the NATO long-term strategy of «openness» in interrelations ...
I. Kuznetsov
doaj +1 more source
Changes in International Arms Control and China’s Role
China Quarterly of International Strategic Studies, 2020 The international arms control regime has arrived at a crossroads as the United States pulls out of a number of international treaties and launches a new round of defense and military buildup in pursuit of absolute strategic and technological superiority.
Chunsi Wu
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source