Results 51 to 60 of about 16,296,718 (378)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Russia’s Current Nuclear Modernization and Arms Control

Journal for Peace and Nuclear Disarmament, 2018
Russia’s strategic modernization program suggests that it is determined to continue its reliance on nuclear weapons as a key element of its national security strategy. The US is now also committed to the large-scale modernization of its strategic forces.
Pavel Podvig
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

The COVID-19 infection control arms race

Infection control and hospital epidemiology, 2020
US hospitals are engaged in an infection control arms race. Hospitals, specialties, and professional groups are spurring one another on to adopt progressively more aggressive measures in response to COVID-19 that often exceed federal and international ...
C. Rhee, M. Baker, M. Klompas
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Book Review: New Chemical Weapons Convention: Implementation and Prospects [PDF]

, 2000
Review of The New Chemical Weapons Convention: Implementation and Prospects by Michael Bothe, Natalino Ronzitti, and Allan Rosas (1998). This book, a fine-grained, expert-level analysis of several of the most intricate legal and policy issues arising in ...
Koplow, David A
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Reevaluating Conventional Strategies: Harnessing Traditional Structures to Counter Violent Extremism in Pakistan

NUST Journal of International Peace and Stability
Civil-military relations constitute a complex area of international relations through the interaction of military institutions, civil society, and other governmental bureaucracies.
Sardar Jehanzaib Ghalib
doaj   +1 more source

Contemplating a Cyber Weapons Convention: An Exploration of Good Practice and Necessary Preconditions

Baltic Journal of Law & Politics, 2020
Despite being a crucially important domain for states, businesses, and individuals, cyberspace still suffers from a regulation deficit. This article takes up one such dangerously underregulated area: cyber warfare and regulation of cyber weapons.
Kalpokienė Julija, Kalpokas Ignas
doaj   +1 more source

Imperfect bipolarity: The ‘third power’ factor in Soviet-American relations in the nuclear field (1958–1968)

Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика, 2023
30 years after the end of the Cold War, bipolar structure still dominates in the nuclear sphere, although certain nuclear powers are closing the gap with Russia and the United States in terms of strategic arsenals and the system of world politics in ...
V. А. Veselov
doaj   +1 more source