Results 41 to 50 of about 984,623 (303)

EU’S POLICY OF DISARMAMENT AS PART OF ITS NORMATIVE POWER [PDF]

open access: yesCES Working Papers, 2015
This article argues that EU’s policy of Disarmament, Non-Proliferation, and Arms Export Control can be conceptualised into the framework of the normative power.
Roxana HINCU
doaj  

Telangiectasia macularis eruptiva perstans: a report of two cases

open access: yesPifu-xingbing zhenliaoxue zazhi, 2023
Patient one was a 38-year-old man with a 20-year history of red macules and angiotelectasis on the chest and the upper arms. Dermatological examination showed multiple telangiectatic macules on the chest and the upper arms, with a negative Darier's sign.
Qiufeng HUANG   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Australia and the Non-Proliferation and Disarmament Initiative: difficult times for disarmament diplomacy [PDF]

open access: yes, 2013
Australia recognises the critical role that the Treaty on the Non-Proliferation of Nuclear Weapons plays in preventing uncontrolled proliferation and promoting disarmament, and upholding the treaty has long been a core foreign policy goal.
Tanya Ogilvie-White
core  

Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells. [PDF]

open access: yesPLoS ONE, 2013
Alveolar rhabdomyosarcoma (ARMS) is an aggressive childhood muscle sarcoma with a 5-year survival rate of less than 30%. More than 80% of ARMSs harbor a PAX3-FOXO1 fusion transcription factor.
Lingling Liu   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The coat of arms (Armorial Ensigns) of the Swinburne College of Technology

open access: yes, 1969
Hand painted illustration on Strained Vellum of the Swinburne Coat of Arms, executed by hand throughout with the use of eighteen carat gold. The inscription reads: The Armorial Ensigns of the Swinburne College of Technology in the State of Victoria in ...
College of Arms painters
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Arms export controls, subsidies and the WTO exemption [PDF]

open access: yes, 2005
Owing to the World Trade Organization (WTO) exemption that allows governments to subsidize arms exports, the arms trade is one of the few remaining areas of trade where we observe export subsidies.
Garcia-Alonso, Maria D C   +3 more
core   +1 more source

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