Results 191 to 200 of about 22,772,603 (237)

Functional Polymer‐Engineered Magnetic Nanoparticles as Dual‐Modal Theragnostic Probes for Early Alzheimer's Disease Detection and Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen   +8 more
wiley   +1 more source

A Comprehensive In Vitro Approach for Assessing the Physiological Degradation of Medical Implants: The Silkothane Arteriovenous Graft Case Study

open access: yesAdvanced NanoBiomed Research, EarlyView.
Evaluating the degradation of absorbable medical devices in vitro demands physiologically relevant conditions. This study presents a comprehensive framework applied to a three‐layered silk fibroin/polyurethane arteriovenous graft, employing human enzymes at physiological concentrations over 6 months. Multiparametric analyses of both graft structure and
Cristina Oldani   +5 more
wiley   +1 more source

Molecular Details of RNA Interactions With FUS Condensates Altering Assembly, Dynamics, and Aggregation

open access: yesAngewandte Chemie, EarlyView.
Using NMR and molecular simulations, we map how RNA engages FUS LC‐RGG1 within condensates through electrostatic, π‐stacking, and polar contacts. These multivalent RNA contacts help stabilize RNA within FUS condensates while also reshaping condensate composition and dynamics.
Tongyin Zheng   +6 more
wiley   +1 more source

Odor Thresholds in Flavor Science: A Data-Driven Review From Mechanisms to Applications. [PDF]

open access: yesCompr Rev Food Sci Food Saf
Yang S   +8 more
europepmc   +1 more source

Dispersion‐Clamped Crystalline Supramolecular Columnar π‐Stacks of Adamantyl‐Substituted Pyrenes

open access: yesAngewandte Chemie, EarlyView.
Can neutral hydrocarbon π‐systems be forced into perfectly aligned cofacial stacks in crystals? An adamantyl‐decorated pyrene derivative crystallizes into rare translationally zero‐offset π‐columns, producing a short π–π distance below 3.3 Å and a large color shift arising from frontier crystal orbital (FCO) formation. ABSTRACT Despite their importance
Kazutaka Shoyama
wiley   +1 more source

Site Density Governs Switching Reactivity Regimes During Aerobic C─H Oxidation in Mn Single‐Atom Photocatalysts

open access: yesAngewandte Chemie, EarlyView.
Increasing the density of isolated manganese (Mn) atoms in carbon nitride (CNx) photocatalysts does not continuously improve performance. Instead, beyond a critical loading, the polymer support reorganizes, altering charge‐carrier dynamics and oxygen activation while preserving atomic dispersion.
Viktoria Velichko   +14 more
wiley   +1 more source

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