Results 231 to 240 of about 58,906 (283)

Brain aromatase is neuroprotective [PDF]

Journal of Neurobiology, 2001
AbstractThe expression of aromatase, the enzyme that catalyzes the biosynthesis of estrogens from precursor androgens, is increased in the brain after injury, suggesting that aromatase may be involved in neuroprotection. In the present study, the effect of inactivating aromatase has been assessed in a model of neurodegeneration induced by the systemic ...
Inigo Azcoitia, Amanda Sierra, Sérgio Veiga   +2 more
exaly   +5 more sources

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Aromatase and aromatase inhibitors

Breast Cancer, 2001
Aromatase inhibition provides both paracrine/intracrine and endocrine treatment. Recent accumulated data clarified that 3rd generation aromatase inhibitors potently suppress intratumoral estrogen synthesis particularly in postmenopausal patients. In the 2nd-line treatment for metastatic breast cancer patients, aromatase inhibitors achieved results ...
M, Toi, H, Bando, S, Saji
openaire   +2 more sources

Aromatase

Journal of Steroid Biochemistry, 1987
Aromatase catalyzes the conversion of androgens to estrogens through a series of monooxygenations to achieve the 19-desmolation and aromatization of the neutral steroid ring-A structure. We have separated two forms of aromatase, a major (P2a) and a minor (P3) form, from human term placenta through solubilization and chromatography.
Y, Osawa, T, Higashiyama, M, Fronckowiak, N, Yoshida, C, Yarborough   +4 more
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Aromatase and Endometriosis

Seminars in Reproductive Medicine, 2004
Aromatase p450 (p450arom) is the key enzyme for biosynthesis of estrogen, which is an essential hormone for the establishment and growth of endometriosis. There is no detectable aromatase enzyme activity in normal endometrium; therefore, estrogen is not locally produced in endometrium.
Serdar E, Bulun, Zongjuan, Fang, Gonca, Imir, Bilgin, Gurates, Mitsutoshi, Tamura, Bertan, Yilmaz, David, Langoi, Sanober, Amin, Sijun, Yang, Santanu, Deb   +9 more
openaire   +2 more sources

Aromatase Inhibitors

Current Medical Research and Opinion, 2001
The new non-steroidal and steroidal aromatase inhibitors are at least as effective as megestrol acetate (MA) as second-line hormonal agents in postmenopausal women with breast cancer. However, they are superior to MA in terms of tolerability and adverse effects.
G H, Cunnick, K, Mokbel
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Inhibition of Aromatase in Vitro and in Vivo by Aromatase Inhibitors

Journal of Enzyme Inhibition, 1990
(1990). Inhibition of Aromatase in Vitro and in Vivo by Aromatase Inhibitors. Journal of Enzyme Inhibition: Vol. 4, No. 2, pp. 179-186.
A S, Bhatnagar, A, Häusler, K, Schieweck   +2 more
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Aromatase, Aromatase Inhibitors, and Breast Cancer

American Journal of Therapeutics, 2001
Estrogens are involved in numerous physiologic processes and have crucial roles in particular disease states, such as mammary carcinomas. Estradiol, the most potent endogenous estrogen, is biosynthesized from androgens by the cytochrome P-450 enzyme complex called aromatase.
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Aromatase Overexpression: Is Aromatase an Oncogene

2001
To directly test the role of aromatase overexpression in tumorigenesis, we have developed a transgenic mouse model and demonstrated for the first time that increased tissue estrogens due to the overexpression of aromatase in mammary glands leads to the induction of various preneoplastic and neoplastic changes that are similar to early breast cancer ...
Rajeshwar Rao Tekmal, Kiran Gill, Nameer Kirma   +2 more
openaire   +1 more source