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Nature Reviews Endocrinology, 2011
Aromatase, an enzyme located in the endoplasmic reticulum of estrogen-producing cells, catalyzes the rate-limiting step in the conversion of androgens to estrogens in many tissues. The clinical features of patients with defects in CYP19A1, the gene encoding aromatase, have revealed a major role for this enzyme in epiphyseal plate closure, which has ...
Wit, J.M., Hero, M., Nunez, S.B.
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Aromatase inhibition by flavonoids

The Journal of Steroid Biochemistry and Molecular Biology, 1990
Several synthetic flavones were found to inhibit the aromatization of androstenedione to estrone catalyzed by human placental microsomes. Twenty-one compounds were tested and the IC50 of the most active were: flavone, 10 microM; 7-hydroxyflavone, 0.5 microM; 7,4'-dihydroxyflavone, 2.0 microM; flavanone, 8.0 microM; and 4'-hydroxyflavanone, 10 microM ...
A R, Ibrahim, Y J, Abul-Hajj
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Aromatase in Aging Women

Seminars in Reproductive Medicine, 1999
Cessation of ovarian estrogen secretion is the key event during the climacteric. An enzyme termed aromatase in a number of human tissues and cells, including ovarian granulosa cells, the placental syncytiotrophoblast, adipose and skin fibroblasts, bone, and the brain, catalyzes the conversion of C19 steroids to estrogens.
S E, Bulun, K, Zeitoun, H, Sasano, E R, Simpson +3 more
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Human Aromatase