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Laterality of Breast Radiotherapy and Ischemic Heart Disease by Cardiovascular Risk Burden.
JAMA Netw OpenChung SY, Noh OK.
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Brain aromatase is neuroprotective
Journal of Neurobiology, 2001AbstractThe expression of aromatase, the enzyme that catalyzes the biosynthesis of estrogens from precursor androgens, is increased in the brain after injury, suggesting that aromatase may be involved in neuroprotection. In the present study, the effect of inactivating aromatase has been assessed in a model of neurodegeneration induced by the systemic ...
Amanda Sierra +2 more
exaly +4 more sources
Aromatase and aromatase inhibitors
Breast Cancer, 2001Aromatase inhibition provides both paracrine/intracrine and endocrine treatment. Recent accumulated data clarified that 3rd generation aromatase inhibitors potently suppress intratumoral estrogen synthesis particularly in postmenopausal patients. In the 2nd-line treatment for metastatic breast cancer patients, aromatase inhibitors achieved results ...
M, Toi, H, Bando, S, Saji
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Journal of Steroid Biochemistry, 1987
Aromatase catalyzes the conversion of androgens to estrogens through a series of monooxygenations to achieve the 19-desmolation and aromatization of the neutral steroid ring-A structure. We have separated two forms of aromatase, a major (P2a) and a minor (P3) form, from human term placenta through solubilization and chromatography.
Y, Osawa +4 more
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Aromatase catalyzes the conversion of androgens to estrogens through a series of monooxygenations to achieve the 19-desmolation and aromatization of the neutral steroid ring-A structure. We have separated two forms of aromatase, a major (P2a) and a minor (P3) form, from human term placenta through solubilization and chromatography.
Y, Osawa +4 more
openaire +2 more sources
Seminars in Reproductive Medicine, 2004
Aromatase p450 (p450arom) is the key enzyme for biosynthesis of estrogen, which is an essential hormone for the establishment and growth of endometriosis. There is no detectable aromatase enzyme activity in normal endometrium; therefore, estrogen is not locally produced in endometrium.
Serdar E, Bulun +9 more
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Aromatase p450 (p450arom) is the key enzyme for biosynthesis of estrogen, which is an essential hormone for the establishment and growth of endometriosis. There is no detectable aromatase enzyme activity in normal endometrium; therefore, estrogen is not locally produced in endometrium.
Serdar E, Bulun +9 more
openaire +2 more sources
Current Medical Research and Opinion, 2001
The new non-steroidal and steroidal aromatase inhibitors are at least as effective as megestrol acetate (MA) as second-line hormonal agents in postmenopausal women with breast cancer. However, they are superior to MA in terms of tolerability and adverse effects.
G H, Cunnick, K, Mokbel
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The new non-steroidal and steroidal aromatase inhibitors are at least as effective as megestrol acetate (MA) as second-line hormonal agents in postmenopausal women with breast cancer. However, they are superior to MA in terms of tolerability and adverse effects.
G H, Cunnick, K, Mokbel
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Inhibition of Aromatase in Vitro and in Vivo by Aromatase Inhibitors
Journal of Enzyme Inhibition, 1990(1990). Inhibition of Aromatase in Vitro and in Vivo by Aromatase Inhibitors. Journal of Enzyme Inhibition: Vol. 4, No. 2, pp. 179-186.
A S, Bhatnagar +2 more
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Annual Review of Physiology, 2002
▪ Abstract There is growing awareness that androgens and estrogens have general metabolic roles that are not directly involved in reproductive processes. These include actions on vascular function, lipid and carbohydrate metabolism, as well as bone mineralization and epiphyseal closure in both sexes.
Evan R, Simpson +7 more
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▪ Abstract There is growing awareness that androgens and estrogens have general metabolic roles that are not directly involved in reproductive processes. These include actions on vascular function, lipid and carbohydrate metabolism, as well as bone mineralization and epiphyseal closure in both sexes.
Evan R, Simpson +7 more
openaire +2 more sources