Results 101 to 110 of about 381,921 (325)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Statistical approach for insulation coordination of high voltage substation exposed to lightning strikes

Electrical engineering & Electromechanics
Introduction. Insulation coordination requires accurate prediction of overvoltages at various points within a substation. Computer simulations of electromagnetic transients in real structures of substations become more precise due to the improvements of ...
S. Bedoui, A. Bayadi
doaj   +1 more source

The Influence of Atmospheric Overvoltages on High-Voltage SF6 Substations [PDF]

, 2011
Very fast overvoltages are characteristic of high-voltage metal-enclosed SF6 insulated substations. During the transient phenomenon, on the SF6 substation enclosure an undesired, short-lasting induced overvoltage may appear, which cannot be prevented ...
Marinko Barukčić, Vedran Vukasović, Zoran Baus   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Flashback flame arrester devices for fuel cargo tank vapor vents [PDF]

The flame quenching capability of four types of flame arresting devices suitable for installation on fuel cargo tank vents of marine transport vessels is evaluated.
Bjorklund, R. A., Kushida, R. O.
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Study on the Failure Causes and Improvement Measures of Arresters in 10 kV Distribution Transformer Areas

Energies
In recent years, arresters in 10 kV distribution transformer areas of the Guangdong power grid have exhibited a rising trend of premature failures, posing a serious threat to distribution network reliability.
Taishan Hu, Yuanzhi Wu, Zhiming Liao, Gang Liu, Shangmao Hu, Yongxia Han, Lu Qu, Licheng Li   +7 more
doaj   +1 more source

A Field Observation on Lightning Performance Improvement of Overhead Distribution Lines [PDF]

, 2009
Two feeders of 20 kV overhead distribution lines which are located in a high lightning density area are chosen to be observed as a field study due to their good lightning performance after improvement of lightning protection system.
Hidayat, S. (Syarif), Mardiana, R. (Redy), Mefiardhi, R. (Ryan), Zoro, R. (Reynaldo)   +3 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source