Results 71 to 80 of about 7,913 (283)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

High-Frequency Test of Electric Locomotive Arrester and Its PHM Design

Energies
The zinc oxide (ZnO) arrester is positioned on the locomotive roof, preventing other onboard electrical equipment from being harmed by external and internal overvoltages.
Xinping Peng, Huanqing Zou, Pengfei Wang, Kejian Song, Ganghui Xie   +4 more
doaj   +1 more source

Kajian Pemasangan Lightning Arrester pada Sisi Hv Transformator Daya Unit Satu Gardu Induk Teluk Betung [PDF]

, 2017
Generally, The power centers are connected to the air transmission line, and the airborne transmission channel is susceptible to disturbances that are affected from outside the system, one of which is a lightning strike.
Jurnal, R. T. (Redaksi)
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Detonation-flame arrester devices for gasoline cargo vapor recovery systems [PDF]

Empirical data on the deflagration-to-detonation run-up distance for flowing mixtures of gasoline and air in 15.2-cm- (6.0-in.-) diameter piping simulating a vapor recovery system are presented.
Bjorklund, R. A., Ryason, P. R.
core   +1 more source

Perancangan Sistem Proteksi Petir Internal Pada Condotel Borobudur Blimbing Kota Malang [PDF]

, 2014
Sambaran petir merupakan ancaman bagi gedung bertingkat. Pada gedung Condotel Borobudur Blimbing Kota Malang yang masih dalam tahap perencanaan pembangunan perlu dirancang system proteksi petir internal agar dapat melindungi seluruh peralatan di dalam ...
Ir. Soemarwanto, MT., Priya Surya Harijanto., Drs. Ir. Moch. Dhofir, MT
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A METHOD OF DETERMINING THE ABILITY OF THE ARRESTER TO ABSORB ENERGY WITHOUT BREAKING THE HEAT BALANCE

Electrical engineering & Electromechanics, 2015
Purpose.The aim of this study is to obtain a method for determining the capacity surge arrester nonlinear absorb energy without breaking the heat balance in modes of long-term application of operating voltage, which allows for analysis of their work in ...
S.Yu. Shevchenko
doaj  

Accurate Surge Arrester Modeling for Optimal Risk-Aware Lightning Protection Utilizing a Hybrid Monte Carlo–Particle Swarm Optimization Algorithm

Technologies
The application of arresters is critical for the safe operation of electric grids against lightning. Arresters limit the consequences of lightning-induced over-voltages.
Amir Hossein Kimiai Asadi, Mohsen Eskandari, Hadi Delavari   +2 more
doaj   +1 more source

Application and Analysis for Surge Arrester on Lightning Protection of Distribution Network

MATEC Web of Conferences, 2016
In order to effectively reduce lightning stroke outage rate, effect of lightning protection with surge arrester on transmission line has been generally acknowledged relative to other lightning protection measures.
Wang Daxing, He Bin, Zhong Wei, Lin Bo, Wang Dong, Li Tingbin   +5 more
doaj   +1 more source