Results 51 to 60 of about 1,571,346 (349)

Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles [PDF]

, 2017
Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in ectopic beats.
Panfilov, Alexander, Seemann, Gunnar, Van Nieuwenhuyse, Enid, Vandersickel, Nele   +3 more
core   +7 more sources

Frequency of Cardiac Arrhythmias in Hypertensive Patients

Pakistan Armed Forces Medical Journal, 2022
Objective: To determine the frequency of cardiac arrhythmias in hypertensive patients. Study Design: Analytical Cross -sectional study. Place & Duration of Study: Tertiary Cardiac Center, Lahore Pakistan from Jan 2021 to Dec2021. Methodology:
Muhammad Naeem Tariq, Naseer Ahmed Samore, Muhammad Humayoun Rashid, Sohail Aziz, Ghoza Chaudhery, Jahanzab Ali, Naseem Azad, Ahmad Noeman, Syeda Neelam Yamin Bukhari, Azhar Ali Chaudhry   +9 more
doaj   +1 more source

Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome

Frontiers in Pharmacology, 2022
Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia.
Elena Zaklyazminskaya, Elena Zaklyazminskaya, Anna Shestak, Dmitry Podolyak, Vera Komoliatova, Leonid Makarov, Anna Novitskaya, Amiran Revishvili   +7 more
doaj   +1 more source

Itraconazole-induced Torsade de Pointes in a patient receiving methadone substitution therapy [PDF]

, 2009
Issues. Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors. Approach and Key Findings.
Narayanan, S., Robson , Noorzurani, Vicknasingam, B.   +2 more
core  

Early detection of biochemically occult autonomous thyroid nodules [PDF]

, 2016
Objective: Autonomously functioning thyroid areas may be associated with subclinical or overt hyperthyroidism, but may exist even in the presence of normal TSH.
Brusca, Nunzia, Capriello, Silvia, Cellini, Miriam, Centanni, Marco, Gargano, L., Salvatori, R., Santaguida, MARIA GIULIA, Virili, Camilla   +7 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Arrhythmias May Hide a Genetic Cardiomyopathy in Left Ventricular Hypertrabeculation in Children: A Single-Center Experience

Children
Background. Left ventricular hypertrabeculation (LVHT) is a myocardial disorder with different clinical manifestations, from total absence of symptoms to heart failure, arrhythmias, sudden cardiac death (SCD), and thromboembolic events. It is challenging
Irma Battipaglia, Nicoletta Cantarutti, Marianna Cicenia, Rachele Adorisio, Virginia Battista, Anwar Baban, Massimo Stefano Silvetti, Fabrizio Drago   +7 more
doaj   +1 more source

Cardiac Arrhythmia and Geomagnetic Activity [PDF]

, 2006
Background: The purpose of this paper is a review of a number of studies considering links between life threatening cardiac arrhythmias, sudden cardiac death (SCD) and the level of environmental physical activity factors like geomagnetic activity (GMA)
Stoupel, E
core   +2 more sources

Management of asymptomatic arrhythmias: a European Heart Rhythm Association (EHRA) consensus document, endorsed by the Heart Failure Association (HFA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin America Hear

Europace, 2019
Asymptomatic arrhythmias are frequently encountered in clinical practice. Although studies specifically dedicated to these asymptomatic arrhythmias are lacking, many arrhythmias still require proper diagnostic and prognostic evaluation and treatment to ...
D. Arnar, G. Mairesse, G. Boriani, H. Calkins, A. Chin, A. Coats, J. Deharo, J. Svendsen, H. Heidbüchel, R. Isa, J. Kalman, D. Lane, R. Louw, G. Lip, P. Maury, T. Potpara, F. Sacher, P. Sanders, N. Varma, L. Fauchier   +19 more
semanticscholar   +1 more source

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source