Results 71 to 80 of about 1,569,657 (332)

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]

, 2015
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina, Beltran-Alvarez, Pedro, Berne, Paola, Bosch Calero, Cristina, Brugada, Josep, Brugada, Ramon, Campuzano, Oscar, Iglesias, Anna, Pérez, Carmelo, Pérez, Guillermo J., Ruiz Hernandez, Pablo M., Scornik, Fabiana S., Wangüemert, Fernando   +12 more
core   +2 more sources

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Prevalence of arterial hypertension in young elite athletes with a hypertensive type of response to physical activity

Спортивная медицина: наука и практика
Aim of the study: to assess the prevalence of arterial hypertension in athletes with high BP values during an exercise test.Methods: out of 2313 athletes 14–18 (15.5 ± 1.4) years old, according to the results of VEM, 128 (6 %; 60 m) people with high ...
V. N. Komoliatova, D. A. Besportochnii, L. M. Makarov, I. I. Kiseleva, N. V. Aksenova   +4 more
doaj   +1 more source

Retrospective study of the correlation of serum potassium concentrations and the findings of heart auscultation in calves with neonatal diarrhea [PDF]

, 1980
A retrospective study was conducted of clinical records of calves with neonatal diarrhea up to the age of 14 days concerning certain aspects of blood potassium concentration and heart rate and rhythm.
Acres, Stephen D., Klee, Wolfgang
core   +1 more source

Ventricular Arrhythmias in Cardiac Sarcoidosis

Circulation, 2018
The diagnosis of cardiac sarcoidosis (CS), especially in cases where there is limited or no extracardiac involvement, is challenging. Patients with CS are at increased risk of ventricular arrhythmias and sudden cardiac death.
D. Okada, John Smith, A. Derakhshan, Zain Gowani, Satish Misra, R. Berger, H. Calkins, H. Tandri, J. Chrispin   +8 more
semanticscholar   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Is there a utility for QRS dispersion in clinical practice? [PDF]

, 2017
Prognostic markers derived from standard ECG have always been seductive. Increased dispersion of durations of the P wave, of the QRS complex, or of the QT interval has been associated with the risk of atrial fibrillation, ventricular arrhythmias, sudden ...
Chávez-González, Elibet, Donoiu, Ionuț, Târtea, Georgică Costinel   +2 more
core   +7 more sources

"Re-evaluation of variants of uncertain significance in patients with hereditary arrhythmogenic disorders"

BMC Cardiovascular Disorders
Background Genetic diagnostics support the diagnosis of hereditary arrhythmogenic diseases, but variants of uncertain significance (VUS) complicate matters, emphasising the need for regular reassessment.
Sarah Martin, Tina Jenewein, Christof Geisen, Stefanie Scheiper-Welling, Silke Kauferstein   +4 more
doaj   +1 more source

Incident cardiac arrhythmias associated with metabolic dysfunction-associated steatotic liver disease: a nationwide histology cohort study

Cardiovascular Diabetology, 2023
Background Prior studies suggest a link between metabolic dysfunction-associated steatotic liver disease (MASLD) and incident arrhythmias, including atrial fibrillation (AF).
Tracey G. Simon, Fahim Ebrahimi, Bjorn Roelstraete, Hannes Hagström, Johan Sundström, Jonas F. Ludvigsson   +5 more
doaj   +1 more source

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source