Results 11 to 20 of about 224,975 (295)

PRRX1 Loss‐of‐Function Mutations Underlying Familial Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Atrial fibrillation (AF) is the most common form of clinical cardiac dysrhythmia responsible for thromboembolic cerebral stroke, congestive heart failure, and death. Aggregating evidence highlights the strong genetic basis of AF. Nevertheless,
Xiao‐Juan Guo, Xing‐Biao Qiu, Jun Wang, Yu‐Han Guo, Chen‐Xi Yang, Li Li, Ri‐Feng Gao, Zun‐Ping Ke, Ruo‐Min Di, Yu‐Min Sun, Ying‐Jia Xu, Yi‐Qing Yang   +11 more
doaj   +1 more source

Cardiac resynchronization therapy and its effects in patients with type 2 DIAbetes mellitus OPTimized in automatic vs. echo guided approach. Data from the DIA-OPTA investigators

Cardiovascular Diabetology, 2020
Objectives To evaluate the effects of cardiac resynchronization therapy (CRTd) in patients with type 2 diabetes mellitus (T2DM) optimized via automatic vs. echocardiography-guided approach.
Celestino Sardu, Pasquale Paolisso, Valentino Ducceschi, Matteo Santamaria, Cosimo Sacra, Massimo Massetti, Antonio Ruocco, Raffaele Marfella   +7 more
doaj   +1 more source

Double-Outlet Left Ventricle: Case Series and Systematic Review of the Literature

Diagnostics, 2023
Double-outlet left ventricle (DOLV) is an abnormal ventriculo-arterial connection characterized by the origin of both great arteries from the morphological left ventricle. The aim of our paper is to describe the morphological and imaging features of DOLV
Michele Lioncino, Giulio Calcagni, Fausto Badolato, Giovanni Antonelli, Benedetta Leonardi, Andrea de Zorzi, Aurelio Secinaro, Gianluca Brancaccio, Sonia Albanese, Adriano Carotti, Fabrizio Drago, Gabriele Rinelli   +11 more
doaj   +1 more source

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic Analyses

Cells, 2023
Despite many efforts to treat atrial fibrillation (AF), the most common progressive and age-related cardiac tachyarrhythmia in the Western world, the efficacy is still suboptimal. A plausible reason for this is that current treatments are not directed at
Fabries G. Huiskes, Esther E. Creemers, Bianca J. J. M. Brundel   +2 more
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Hot or cold? Feasibility, safety, and outcome after radiofrequency‐guided versus cryoballoon‐guided left atrial appendage isolation

Journal of Arrhythmia, 2022
Background Left atrial appendage (LAA) isolation (LAAI) has been described as an adjunctive ablation strategy for patients with recurrent atrial tachyarrhythmia (ATa).
Shota Tohoku, Shaojie Chen, Stefano Bordignon, Julian Kyoung‐Ryul Chun, Boris Schmidt   +4 more
doaj   +1 more source

Successful catheter cryoablation for premature ventricular contractions originating from the para‐Hisian region

Clinical Case Reports, 2019
We achieved successful catheter cryoablation in a patient with para‐Hisian premature ventricular contractions (PVCs) without conduction disturbance using the freeze‐thaw‐freeze method while observing the atrial‐His bundle interval.
George Suzuki, Akihiko Yotsukura, Tadafumi Nanbu, Masayuki Sakurai   +3 more
doaj   +1 more source

Pediatric Left Posteroseptal Accessory Pathway Ablation from Giant Coronary Sinus with Persistent Left Superior Cava

Journal of Cardiovascular Development and Disease, 2022
We report a pediatric patient with persistent left superior vena cava and a D-transposition of great arteries, which is an uncommon relation. It is crucial to know the anatomy of the persistent left superior vena cava and the dilated coronary sinus to ...
José Cruzalegui, Sergi Cesar, Oscar Campuzano, Victoria Fiol, Josep Brugada, Georgia Sarquella-Brugada   +5 more
doaj   +1 more source

Pediatric Malignant Arrhythmias Caused by Rare Homozygous Genetic Variants in TRDN: A Comprehensive Interpretation

Frontiers in Pediatrics, 2021
Aim: To perform a comprehensive phenotype-genotype correlation of all rare variants in Triadin leading to malignant arrhythmias in pediatrics.Methods: Triadin knockout syndrome is a rare entity reported in pediatric population. This syndrome is caused by
Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Anna Fernandez-Falgueras, Sergi Cesar, Elena Arbelo, Elena Arbelo, Paloma Jordà, Paloma Jordà, Ana García-Álvarez, Ana García-Álvarez, Jose Carlos Cruzalegui, Erika Fernanda Merchan, Victoria Fiol, Josep Brugada, Josep Brugada, Josep Brugada, Ramon Brugada, Ramon Brugada, Ramon Brugada, Ramon Brugada, Oscar Campuzano, Oscar Campuzano, Oscar Campuzano   +22 more
doaj   +1 more source

REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundHeart failure is a complex syndrome characterized by cardiac contractile impairment with high mortality. Defective intracellular Ca2+ homeostasis is the central cause under this scenario and tightly links to ultrastructural rearrangements of ...
Lei Yao, Duanyang Xie, Li Geng, Dan Shi, Jian Huang, Yufei Wu, Fei Lv, Dandan Liang, Li Li, Yi Liu, Jun Li, Yi‐Han Chen   +11 more
doaj   +1 more source

Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Frontiers in Physiology, 2023
Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in isolated ventricular cardiomyocytes (CMs). However, other studies with SGLT2i have yielded conflicting results.
Sha Chen, Sha Chen, Cees A. Schumacher, Cees A. Schumacher, Shirley C. M. Van Amersfoorth, Shirley C. M. Van Amersfoorth, Jan W. T. Fiolet, Jan W. T. Fiolet, Antonius Baartscheer, Antonius Baartscheer, Marieke W. Veldkamp, Marieke W. Veldkamp, Ruben Coronel, Ruben Coronel, Coert J. Zuurbier, Coert J. Zuurbier   +15 more
doaj   +1 more source