Results 31 to 40 of about 71,558 (258)

Pediatric Malignant Arrhythmias Caused by Rare Homozygous Genetic Variants in TRDN: A Comprehensive Interpretation

Frontiers in Pediatrics, 2021
Aim: To perform a comprehensive phenotype-genotype correlation of all rare variants in Triadin leading to malignant arrhythmias in pediatrics.Methods: Triadin knockout syndrome is a rare entity reported in pediatric population. This syndrome is caused by
Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Anna Fernandez-Falgueras, Sergi Cesar, Elena Arbelo, Elena Arbelo, Paloma Jordà, Paloma Jordà, Ana García-Álvarez, Ana García-Álvarez, Jose Carlos Cruzalegui, Erika Fernanda Merchan, Victoria Fiol, Josep Brugada, Josep Brugada, Josep Brugada, Ramon Brugada, Ramon Brugada, Ramon Brugada, Ramon Brugada, Oscar Campuzano, Oscar Campuzano, Oscar Campuzano   +22 more
doaj   +1 more source

Inherited cardiac arrhythmias

, 2020
The main inherited cardiac arrhythmias are long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome.
Schwartz, Peter J., Antzelevitch, Charles, Wilde, Arthur A. M., Bezzina, Connie R., Ackerman, Michael J., Cuneo, Bettina F., Borggrefe, Martin   +6 more
core   +1 more source

REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundHeart failure is a complex syndrome characterized by cardiac contractile impairment with high mortality. Defective intracellular Ca2+ homeostasis is the central cause under this scenario and tightly links to ultrastructural rearrangements of ...
Lei Yao, Duanyang Xie, Li Geng, Dan Shi, Jian Huang, Yufei Wu, Fei Lv, Dandan Liang, Li Li, Yi Liu, Jun Li, Yi‐Han Chen   +11 more
doaj   +1 more source

Mitochondria and arrhythmias

Free Radical Biology and Medicine, 2014
Mitochondria are essential to providing ATP, thereby satisfying the energy demand of the incessant electrical activity and contractile action of cardiac muscle. Emerging evidence indicates that mitochondrial dysfunction can adversely affect cardiac electrical functioning by impairing the intracellular ion homeostasis and membrane excitability through ...
Kai-Chien, Yang, Marcelo G, Bonini, Samuel C, Dudley   +2 more
openaire   +3 more sources

LRP6 acts as a scaffold protein in cardiac gap junction assembly

Nature Communications, 2016
LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes
Jun Li, Changming Li, Dandan Liang, Fei Lv, Tianyou Yuan, Erlinda The, Xiue Ma, Yahan Wu, Lixiao Zhen, Duanyang Xie, Shiyi Wang, Yuan Liu, Jian Huang, Jingyi Shi, Yi Liu, Dan Shi, Liang Xu, Li Lin, Luying Peng, Jianmin Cui, Weidong Zhu, Yi-Han Chen   +21 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Frontiers in Physiology, 2023
Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in isolated ventricular cardiomyocytes (CMs). However, other studies with SGLT2i have yielded conflicting results.
Sha Chen, Sha Chen, Cees A. Schumacher, Cees A. Schumacher, Shirley C. M. Van Amersfoorth, Shirley C. M. Van Amersfoorth, Jan W. T. Fiolet, Jan W. T. Fiolet, Antonius Baartscheer, Antonius Baartscheer, Marieke W. Veldkamp, Marieke W. Veldkamp, Ruben Coronel, Ruben Coronel, Coert J. Zuurbier, Coert J. Zuurbier   +15 more
doaj   +1 more source

Role of the Purkinje system in heritable arrhythmias

, 2019
Much has been written about arrhythmias in structurally normal hearts. In this review, we focus on rapid ventricular arrhythmias that occur in hearts having a pathogenic genetic variant that has been found in families in which arrhythmias occur.
Wilde, Arthur A.M., Boyden, Penelope A., Garan, Hasan   +2 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Investigation of the prevalence of Cognitive Impairment and its risk factors within the elderly population in Shanghai, China

Scientific Reports, 2018
To investigate the prevalence of cognitive impairment and its risk factors among Chinese elders aged over 80 years, a community-based, cross-sectional study was conducted from May to June 2016 in Shanghai, China.
Longbing Ren, Yongtao Zheng, Lezhou Wu, Yijun Gu, Yusheng He, Bo Jiang, Jie Zhang, Lijuan Zhang, Jue Li   +8 more
doaj   +1 more source