Results 31 to 40 of about 140,818 (174)
Advanced Science, EarlyView.Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li +21 more
wiley +1 more source
Clinical Cardiology, Volume 45, Issue 12, Page 1229-1235, December 2022., 2022 Abstract Background Cryoballoon ablation (CBA) is recommended for patients with symptomatic drug refractory paroxysmal atrial fibrillation (pAF). However, substantial atrial fibrillation (AF) recurrence is common during follow‐up. Searching for a potential biomarker representing both myocardial injury and inflammation to identify patients at high risk ...
Xinxin Li +9 more
wiley +1 more source
Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices
Advanced Science, EarlyView.In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley +1 more source
Clinical Cardiology, Volume 45, Issue 12, Page 1184-1191, December 2022., 2022 Abstract Background As previously reported, impairment of left ventricular global longitudinal strain (LVGLS) is associated with myocardial fibrosis, arrhythmias, and heart failure in hypertrophic cardiomyopathy (HCM) patients. Hypothesis This study aimed to estimate the association between LVGLS measured by echocardiography and major adverse ...
Ying Yang +3 more
wiley +1 more source
Advanced Science, EarlyView.This study shows that Foxp1 regulates the USP20–HIF1ɑ‐Hand1 pathway, controlling cardiomyocyte metabolic reprogramming, proliferation, and heart regeneration. By targeting Hand1, the downstream effector, this work suggests a promising molecular target for gene therapy of heart failure, potentially guiding the development of novel molecular ...
Yanfang Wang +19 more
wiley +1 more source
Microneedles at the Forefront of Next Generation Theranostics
Advanced Science, EarlyView.The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang +8 more
wiley +1 more source
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background Calreticulin (CRT), an endoplasmic reticulum–resident protein generally overexpressed in cancer cells, is associated with radiation resistance. CRT shows higher transacetylase activity, as shown by us earlier, in the presence of the polyphenolic acetates (like 7, 8‐diacetoxy‐4‐methylcoumarin, DAMC) and modifies the activity of a ...
Amit Verma +6 more
wiley +1 more source
Advanced Science, EarlyView.This study explores the roles of cardiomyocyte‐ and cardiac fibroblast‐specific EP4 in isoproterenol‐induced cardiac fibrosis. The findings reveal that EP4 inhibition improves diastolic function and reduces fibrosis by modulating TGF‐β1 signaling and extracellular matrix protein production.
Hu Xu +16 more
wiley +1 more source
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, EarlyView.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
wiley +1 more source
Arrhythmia Detection using Mutual Information-Based Integration Method [PDF]
arXiv, 2015 The aim of this paper is to propose an application of mutual information-based ensemble methods to the analysis and classification of heart beats associated with different types of Arrhythmia. Models of multilayer perceptrons, support vector machines, and radial basis function neural networks were trained and tested using the MIT-BIH arrhythmia ...
arxiv