Results 61 to 70 of about 228,705 (316)

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Recommendations for participation in leisure-time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions. Part 2: ventricular arrhythmias, channelopathies, and implantable defibrillators.

, 2020
This paper belongs to a series of recommendation documents for participation in leisure-time physical activity and competitive sports by the European Association of Preventive Cardiology (EAPC).
Castelletti, Silvia, Castelletti, S, Boveda, S, Schwartz, Peter J, Zeppenfeld, Katja, Miljoen, H, Arbelo, Elena, Sanz de la Garza, María, Heidbuchel, H, Saenen, J, Sanz de la Garza, M, Corrado, D, Miljoen, Hielko, D'Ascenzi, F, Boveda, Serge, Börjesson, Mats,, Schwartz, PJ, Castelletti, S., Heidbuchel, Hein, Papadakis, Michael, Papadakis, M., Niebauer, J, Garza, M.S. de la, Pelliccia, Antonio, Corrado, D., Mont, L, Sharma, S, Pelliccia, A, Zeppenfeld, K, Boveda, S., Sharma, S., Corrado, Domenico, D'Ascenzi, Flavio, Heidbuchel, H., Borjesson, M, Niebauer, Josef, Saenen, Johan, Heidb\ufcchel, Hein, Arbelo, E, Zeppenfeld, K., Papadakis, M, Borjesson, Mats, Mont, Lluis, Mont, L., Saenen, J., Niebauer, J., Pelliccia, A., Miljoen, H., Schwartz, Peter J., D'Ascenzi, F., Sharma, Sanjay, Schwartz, P.J., Arbelo, E., Borjesson, M.   +53 more
core   +1 more source

Cardiac arrhythmias in Dravet syndrome: an observational multicenter study [PDF]

, 2020
Objectives: We ascertained the prevalence of ictal arrhythmias to explain the high rate of sudden unexpected death in epilepsy (SUDEP) in Dravet syndrome (DS).
Thijs, Roland D., Judith S. Verhoeven, Helling, Robert M, Tan, Hanno L., W. Boudewijn Gunning, J. Helen Cross, Sander, Josemir W., Sharon Shmuely, Robert M. Helling, Verhoeven, Judith S, Cross, J. Helen, Eva H. Brilstra, Helling, Robert M., Verhoeven, Judith S., Gunning, W. Boudewijn, Sisodiya, Sanjay M., Shmuely, Sharon, Roland D. Thijs, Brilstra, Eva H, Thijs, Roland D, Sisodiya, Sanjay M, Surges, Rainer, Brilstra, Eva H., Hanno L. Tan, Cross, J Helen, Josemir W. Sander, Tan, Hanno L, Rainer Surges, Sanjay M. Sisodiya, Gunning, W Boudewijn, Sander, Josemir W   +30 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

Nature Communications, 2017
MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options.
Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G. Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, Zuoren Yu   +16 more
doaj   +1 more source

Protecting the ischemic heart : pharmacological protection against myocardial ischemia in rats in vivo and in vitro [PDF]

, 2004
Today in Switzerland approximately 40% of all deaths are due to cardiovascular diseases. More than half of these are due to ischemic heart disease. Among the fatal consequences of ischemic heart disease are life-threatening arrhythmias and myocardial ...
Butz, Silvia
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Arrhythmias May Hide a Genetic Cardiomyopathy in Left Ventricular Hypertrabeculation in Children: A Single-Center Experience

Children
Background. Left ventricular hypertrabeculation (LVHT) is a myocardial disorder with different clinical manifestations, from total absence of symptoms to heart failure, arrhythmias, sudden cardiac death (SCD), and thromboembolic events. It is challenging
Irma Battipaglia, Nicoletta Cantarutti, Marianna Cicenia, Rachele Adorisio, Virginia Battista, Anwar Baban, Massimo Stefano Silvetti, Fabrizio Drago   +7 more
doaj   +1 more source