Results 51 to 60 of about 105,745 (208)

Cardiovascular Characteristics of Patients with Genetic Variation in Desmoplakin (DSP)

Cardiogenetics, 2022
Background: Variants in the desmoplakin (DSP) gene have been recognized in association with the pathogenesis of arrhythmogenic right ventricular cardiomyopathy (ARVC) for nearly 20 years.
Nosheen Reza, Alejandro de Feria, Jessica L. Chowns, Lily Hoffman-Andrews, Laura Vann, Jessica Kim, Amy Marzolf, Anjali Tiku Owens   +7 more
doaj   +1 more source

Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia.

, 2016
Differentiation between early-phase arrhythmogenic right ventricular cardiomyopathy (ARVC) and right ventricular outflow tract (RVOT)-ventricular tachycardia (VT) can be challenging, and correct diagnosis is important. We compared electrocardiogram (ECG)
Haugaa, Kristina, Einar Hopp, Trine F. Haland, Kristina H. Haugaa, Hopp, Einar, Rasmus Borgquist, Leren, Ida S, Ida S. Leren, Jan Otto Beitnes, Edvardsen, Thor, Saberniak, Jørg, Haland, Trine F, Jørg Saberniak, Haugaa, Kristina H, Beitnes, Jan Otto, Thor Edvardsen, Borgquist, Rasmus, Håland, Trine Synnøve Fink, Leren, Ida Skrinde   +18 more
core   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

The disease mutation A77V in Ryanodine receptor RyR2 induces changes in energy conduction pathways in the protein [PDF]

, 2011
Energetically responsive residues of the 217 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. These residues lie along a hydrogen bonded path through the protein.
Nazan Walpoth, Burak Erman
core  

Unique genetic background and outcome of non-Caucasian Japanese probands with arrhythmogenic right ventricular dysplasia/cardiomyopathy. [PDF]

, 2017
滋賀医科大学博士（医学）Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy mainly caused by desmosomal gene mutation.
WADA, Yuko
core   +1 more source

High resolution systematic digital histological quantification of cardiac fibrosis and adipose tissue in phospholamban p.Arg14del mutation associated cardiomyopathy.

PLoS ONE, 2014
Myocardial fibrosis can lead to heart failure and act as a substrate for cardiac arrhythmias. In dilated cardiomyopathy diffuse interstitial reactive fibrosis can be observed, whereas arrhythmogenic cardiomyopathy is characterized by fibrofatty ...
Johannes M I H Gho, René van Es, Nikolas Stathonikos, Magdalena Harakalova, Wouter P te Rijdt, Albert J H Suurmeijer, Jeroen F van der Heijden, Nicolaas de Jonge, Steven A J Chamuleau, Roel A de Weger, Folkert W Asselbergs, Aryan Vink   +11 more
doaj   +1 more source

Evolving Diagnostic Criteria for Arrhythmogenic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Criteria for diagnosis of arrhythmogenic cardiomyopathy (ACM) were first proposed in 1994 and revised in 2010 by a Task Force. Although the Task Force criteria demonstrated a good accuracy for diagnosis of the original right ventricular phenotype ...
Domenico Corrado, Alessandro Zorzi, Alberto Cipriani, Barbara Bauce, Riccardo Bariani, Giorgia Beffagna, Manuel De Lazzari, Federico Migliore, Kalliopi Pilichou, Alessandra Rampazzo, Ilaria Rigato, Stefania Rizzo, Gaetano Thiene, Martina Perazzolo Marra, Cristina Basso   +14 more
doaj   +1 more source

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

Arrhythmogenic Right Ventricular Cardiomyopathy Diagnosis

, 2020
Arrhythmogenic right ventricular cardiomyopathy, formerly called arrhythmogenic right ventricular dysplasia, is an under-recognized clinical entity characterized by ventricular arrhythmias and a characteristic ventricular pathology.
Jason T. Jacobson, Poplawska, Maria, Aronow, Wilbert S, Amer Sayed, Maria Poplawska, Fuisz, Anthon, Frishman, William H, Wilbert S. Aronow, William H. Frishman, Anthon Fuisz, Suman Pal, Sayed, Amer, Jacobson, Jason T, Pal, Suman   +13 more
core   +1 more source

SURGELLA: A Scoping Review of Impella‐Assisted Hemodynamic Support in High‐Risk Non‐Cardiac Surgery

Artificial Organs, EarlyView.
In selected patients with severe LV dysfunction, Impella‐supported non‐cardiac surgery may provide a temporary hemodynamic bridge to otherwise prohibitive procedures. Published evidence remains limited to a small number of highly selected cases, supporting technical feasibility rather than comparative benefit or generalizable safety.
Hussein Elghazaly, Mohammed Allaf, Areeb Mian, Hanad Ahmed, Alex Gordon‐Weeks, Alexander Tindale, Vasileios Panoulas   +6 more
wiley   +1 more source