Results 101 to 110 of about 2,626,293 (190)

Genotype-phenotype correlations in patients with pathogenic/likely pathogenic titin variants from the Swiss Arrhythmogenic Cardiomyopathy Registry

Open Heart
Background Truncating variants in the titin gene (TTNtv) are associated with cardiomyopathy, mainly dilated cardiomyopathy (DCM). The clinical presentation and outcomes of arrhythmogenic phenotypes in these patients are scarcely studied.Methods and ...
Andreas J Flammer, Lorraine Sazgary, Robert Manka, Annina Salome Vischer, Ardan M Saguner, Frank Ruschitzka, Marina Rieder, Siv Fokstuen, Firat Duru, Umberto Maccio, Argelia Medeiros-Domingo, Corinna Brunckhorst, Felix Tanner, Verena Charlotte Wilzeck, Nina Alissa Schätti, Matthias P. Nägele, Fran Mikulicic, Christian Grebmer, Katja E Odening, Nicole R Bonetti   +19 more
doaj   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Carvajal syndrome: a brief overview and clinical case of cardiomyopathy, associated with compound heterozygous mutations of the desmoplakin gene

Российский кардиологический журнал, 2018
Mutations in the genes encoding desmosomal proteins cause a wide range of diseases associated with abnormalities of the skin, hair and heart. In 45-50% these mutations determine the development of arrhythmogenic right ventricular cardiomyopathy.
T. G. Vaikhanskaya, L. N. Sivitskaya, T. V. Kurushko, D. P. Ermakovich, E. V. Zasim, N. G. Danilenko   +5 more
doaj   +1 more source

Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity

MedComm, Volume 7, Issue 9, September 2026.
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu, Yixuan Sheng, Yun Chang, Yuan Chang, Miaomiao Xu, Wenjing Zhou, Wenxiu Wang, Qingyuan Liao, Zhan Shi, Meng Zhang, Feng Lan, Jiangping Song, Xiaoyan Qiu   +12 more
wiley   +1 more source

Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members

, 2014
AimsExercise increases risk of ventricular arrhythmia in subjects with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the impact of exercise on myocardial function in ARVC subjects.
Haugaa, Kristina, Smith, Hans-Jorgen, Smith, Hans-Jørgen, Platonov, Pyotr,, Ribe, Margareth, Holst, Anders G., Hasselberg, Nina E., Edvardsen, Thor, Saberniak, Jørg, Platonov, Pyotr G, Sarvari, Sebastian Imre, Borgquist, Rasmus,, Holst, Anders G, Hasselberg, Nina Eide, Platonov, Pyotr, Borgquist, Rasmus, Lund University., Sarvari, Sebastian I., Haugaa, Kristina H., Saberniak, Jorg   +19 more
core   +1 more source

Miocardiopatia arritmogénica do ventrículo direito. Contribuição de diferentes técnicas de eletrocardiografia

Revista Portuguesa de Cardiologia, 2014
Resumo: A miocardiopatia arritmogénica do ventrículo direito – também denominada de displasia arritmogénica do ventrículo direito – é uma patologia em que se verifica a substituição do miocárdio por tecido fibroso ou fibroadiposo predominantemente no ...
Davide Moreira, Anne Delgado, Bruno Marmelo, Emanuel Correia, Pedro Gama, João Pipa, Luís Nunes, Oliveira Santos   +7 more
doaj   +1 more source

Prenatally diagnosed cleft lip and palate: Prenatal findings, clinical outcomes, genetic results, and sequencing yield in isolated versus non‐isolated cases

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Introduction Cleft lip and palate (CLP) are common congenital disruptions of the orofacial cleft and are associated with numerous genetic conditions. This study examines prenatal findings, clinical outcomes, and genetic findings among prenatally diagnosed CLP, with a focus on the yield of next‐generation sequencing (NGS).
Thomas P. Kishkovich, Gabriela F. Tessler, Meghan Angley, Yijia Zhang, Thomas A. Imahiyerobo, Sherelle L. Laifer‐Narin, Hong Ma, Lynn Simpson, Caitlin D. Baptiste, Jessica L. Giordano, Russell S. Miller, Ronald J. Wapner   +11 more
wiley   +1 more source

Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung, Nitha Aima Muntu, Ulrika Reistam, Jonathan A. Kirk, Marcus Ståhlberg   +4 more
wiley   +1 more source

Understanding arrhythmogenic right ventricular cardiomyopathy.

, 2023
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disease characterized by fibrofatty replacement of myocardial tissue and is an important cause of ventricular dysrhythmias, ventricular dysfunction, and sudden cardiac death ...
Welkie, Regina, PA-C, MSPAS
core   +1 more source

Trends and In‐Hospital Outcomes of Ventricular Tachycardia in Ischemic Versus Non‐Ischemic Dilated Cardiomyopathy—An Insight From the Nationwide Readmissions Database (2016–2020)

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
Lower rates of sudden cardiac arrest and major adverse cardiovascular events in NIDCM patients. Higher rates of in‐hospital mortality, stroke, and heart failure‐related admissions in NIDCM patients. ABSTRACT Background Ventricular tachycardia (VT) is a major cause of morbidity and mortality in patients with structural heart disease, yet real‐world ...
Medhat Chowdhury, Sanchit Duhan, Abdul Rasheed Bahar, Mohamad Hasan Jawadi, Bijeta Keisham, Harini Lakshman, Marc Zughaib, Yasar Sattar, Christopher Bradley, Marcel Zughaib   +9 more
wiley   +1 more source