Results 111 to 120 of about 178,362 (241)

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Beez, Sabine, Demmer, Philipp, Puccetti, Elena   +2 more
core   +3 more sources

INFLUENCE OF MORINGA OLEIFERA (DRUM-STICK) FRUIT EXTRACT ON HAEMATOLOGICAL PROFILE FOLLOWING REPEATED EXPOSURE TO LOW LEVELS OF ARSENIC THROUGH FEED ON RATS [PDF]

, 2012
Effect of Moringa oleifera fruits hot methanolic extract (MFE), if any, in minimizing the adverse reactions of repeated exposure to arsenic trioxide (AT) in feed was investigated in Wistar rats with reference to haematological profile.
Aruna Kumari Singh, K.M. Koley, Lokesh Verma, V.P. Vadlamudi, Vaibhav R. Pachade   +4 more
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Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

Haematologica, 2018
In standard-risk acute promyelocytic leukemia, recent results have shown that all-trans retinoic acid plus arsenic trioxide combinations are at least as effective as classical all-trans retinoic acid plus anthracycline-based chemotherapy while being less
L. Adès, X. Thomas, Agnès Guerci Bresler, E. Raffoux, O. Spertini, N. Vey, T. Marchand, C. Récher, A. Pigneux, S. Girault, E. Deconinck, C. Gardin, O. Tournilhac, J. Lambert, P. Chevallier, S. de Botton, J. Lejeune, H. Dombret, S. Chevret, P. Fenaux   +19 more
semanticscholar   +1 more source

Protective Effect of α-Lipoic Acid Against Arsenic Trioxide–Induced Acute Cardiac Toxicity in Rats

Journal of Pharmacological Sciences, 2011
The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity.
Masafumi Kumazaki, Hitoshi Ando, Akira Sasaki, Taka-aki Koshimizu, Kentarou Ushijima, Keiko Hosohata, Yasuo Oshima, Akio Fujimura   +7 more
doaj   +1 more source

Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress

Leukemia, 2017
Retinoic acid (RA) in association with chemotherapy or with arsenic trioxide (ATO) results in high cure rates of acute promyelocytic leukemia (APL). We show that RA-induced differentiation of human leukemic cell lines and primary blasts dramatically ...
Silvia Masciarelli, Ernestina Capuano, T. Ottone, M. Divona, S. Panfilis, C. Banella, N. Noguera, Alessandra Picardi, G. Fontemaggi, G. Blandino, Francesco Lo-Coco, F. Fazi   +11 more
semanticscholar   +1 more source

Arsenic Trioxide in Patients with Refractory Multiple Myeloma: A Prospective, Phase II, Single-Arm Study [PDF]

Acta Medica Iranica, 2011
Multiple myeloma (MM) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. Recently, arsenic trioxide (ATO), has been considered for treatment refractory MM.
Zohreh Sanaat, Mahtab Rezazadeh, Jalial Vaez Gharamaleki, Jamal Eivazi Ziae, Ali Esfahani   +4 more
doaj   +1 more source

Efficacy of thankuni and grapes in arsenicosis-affected rat

Ukrainian Journal of Veterinary and Agricultural Sciences
This study was undertaken to observe the effects of Thankuni and grapes on hematological and biochemical parameters against arsenicosis in Long Evans rats. Sixty male rats were selected to perform the study.
Md. Feroz Mahmud, Md. Mahmudul Hasan, Md. Bazlar Rashid, Rakibul Islam, Sumon Sarkar, Howard Rodriguez-Mori, Mst. Nasrin Banu   +6 more
doaj   +1 more source

Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1

Haematologica, 2017
Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds.
Maura Gasparetto, Shanshan Pei, Mohammad Minhajuddin, Nabilah Khan, Daniel A. Pollyea, Jason R. Myers, John M. Ashton, Michael W. Becker, Vasilis Vasiliou, Keith R. Humphries, Craig T. Jordan, Clayton A. Smith   +11 more
doaj   +1 more source

Wood Preserving Chemicals and Procedures [PDF]

, 1986
PDF pages ...
Touse, Robert D.
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نقش ارسنيک در القای آپوپتوزيس از مسير Fas در بيماران لوسمی حاد پروميلوسيتی با جابه‌جايی کروموزومی [PDF]

, 2004
لوسمی حاد پروميلوسيتی يکی از زير گروه‌های لوسمی حاد ميلوييدی است که در 15-10% بيماران رخ می‌دهد. حدود 30-20% از اين بيماران که تحت درمان استاندارد با آل‌ترانس رتينوييک اسيد(ATRA) قرار می‌گيرند، در کم‌تر از 1 سال دچار عود می‌شوند. تری‌اکسيد ارسنيک(ATO) به
ارجمند, علیرضا, ذاکر, فرهاد, علی‌مقدم, کامران, قوام‌زاده, اردشیر, معزی, لیلی   +4 more
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